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Science 17 September 1982:
Vol. 217. no. 4565, pp. 1149 - 1151
DOI: 10.1126/science.6287577
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Articles

Science, Vol 217, Issue 4565, 1149-1151
Copyright © 1982 by American Association for the Advancement of Science

articles

Induction of melanized cells from a goldfish erythrophoroma: isolation of pigment translocation variants

J Matsumoto, TJ Lynch, SM Grabowski, JD Taylor, and TT Tchen

Melanization was induced in some cells of a goldfish tumor cell line (GEM-81) by cultivating the cells in autologous serum. The melanized cells continued to proliferate in vitro and several clones were isolated that differed with respect to cell morphology and intracellular distribution of pigment. Some of the clones consisted of cells able to translocate their melanosomes in response to epinephrine, melatonin, or adenosine 3', 5'-monophosphate.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)