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Science 17 September 1982:
Vol. 217. no. 4565, pp. 1104 - 1111
DOI: 10.1126/science.6287576
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Articles

Science, Vol 217, Issue 4565, 1104-1111
Copyright © 1982 by American Association for the Advancement of Science

articles

Regulation of circadian rhythmicity

JS Takahashi and M Zatz

Daily rhythms in many behavioral, physiological, and biochemical functions are generated by endogenous oscillators that function as internal 24-hour clocks. Under natural conditions, these oscillators are synchronized to the daily environmental cycle of light and darkness. Recent advances in locating circadian pacemakers in the brain and in establishing model systems promise to shed light on the cellular and biochemical mechanisms involved in the generation and regulation of circadian rhythms.


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