Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Science 10 September 1982:
Vol. 217. no. 4564, pp. 998 - 1003
DOI: 10.1126/science.7112116

Articles

Science, Vol 217, Issue 4564, 998-1003
Copyright © 1982 by American Association for the Advancement of Science


articles

Biological diversity in metastatic neoplasms: origins and implications

IJ Fidler and IR Hart

Whether neoplasms are unicellular or multicellular in their origin, the process of tumor evolution and progression can rapidly generate biological diversity. Metastases result from the survival and proliferation of specialized subpopulations of cells within the parent tumor. Metastases may have a clonal origin and different metastases may develop from different progenitor cells. However, as with the primary tumor, the origin of metastases is unimportant since the process of tumor evolution and progression can generate biological diversity within and among different metastatic foci.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Oncolytic adenoviruses targeted to cancer stem cells.
J. J. Short and D. T. Curiel (2009)
Mol. Cancer Ther. 8, 2096-2102
   Abstract »    Full Text »    PDF »
CXCL13 Is Highly Produced by Sezary Cells and Enhances Their Migratory Ability via a Synergistic Mechanism Involving CCL19 and CCL21 Chemokines.
M. C. Picchio, E. Scala, D. Pomponi, E. Caprini, M. Frontani, I. Angelucci, A. Mangoni, C. Lazzeri, M. Perez, D. Remotti, et al. (2008)
Cancer Res. 68, 7137-7146
   Abstract »    Full Text »    PDF »
Effect of Amentoflavone on the Inhibition of Pulmonary Metastasis Induced by B16F-10 Melanoma Cells in C57BL/6 Mice.
C. Guruvayoorappan and G. Kuttan (2007)
Integr Cancer Ther 6, 185-197
   Abstract »    PDF »
Evidence for protein 4.1B acting as a metastasis suppressor.
T. Cavanna, E. Pokorna, P. Vesely, C. Gray, and D. Zicha (2007)
J. Cell Sci. 120, 606-616
   Abstract »    Full Text »    PDF »
Increased migration and metastatic potential of tumor cells expressing aquaporin water channels.
J. Hu and A. S. Verkman (2006)
FASEB J 20, 1892-1894
   Abstract »    Full Text »    PDF »
Genetics and biology of pancreatic ductal adenocarcinoma..
A. F. Hezel, A. C. Kimmelman, B. Z. Stanger, N. Bardeesy, and R. A. DePinho (2006)
Genes & Dev. 20, 1218-1249
   Abstract »    Full Text »    PDF »
Dynamic Imaging of Emerging Resistance during Cancer Therapy..
K. C. Lee, D. E. Hall, B. A. Hoff, B. A. Moffat, S. Sharma, T. L. Chenevert, C. R. Meyer, W. R. Leopold, T. D. Johnson, R. V. Mazurchuk, et al. (2006)
Cancer Res. 66, 4687-4692
   Abstract »    Full Text »    PDF »
PD-1 blockade inhibits hematogenous spread of poorly immunogenic tumor cells by enhanced recruitment of effector T cells.
Y. Iwai, S. Terawaki, and T. Honjo (2005)
Int. Immunol. 17, 133-144
   Abstract »    Full Text »    PDF »
1{alpha},25-Dihydroxyvitamin D3 is a preventive factor in the metastasis of lung cancer.
K. Nakagawa, A. Kawaura, S. Kato, E. Takeda, and T. Okano (2005)
Carcinogenesis 26, 429-440
   Abstract »    Full Text »    PDF »
Expression and Functional Role of CCR9 in Prostate Cancer Cell Migration and Invasion.
S. Singh, U. P. Singh, J. K. Stiles, W. E. Grizzle, and J. W. Lillard Jr. (2004)
Clin. Cancer Res. 10, 8743-8750
   Abstract »    Full Text »    PDF »
Manipulation of the Primary Breast Tumor and the Incidence of Sentinel Node Metastases From Invasive Breast Cancer.
N. M. Hansen, X. Ye, B. J. Grube, and A. E. Giuliano (2004)
Arch Surg 139, 634-640
   Abstract »    Full Text »    PDF »
Surgical Removal of Primary Tumor Reverses Tumor-Induced Immunosuppression Despite the Presence of Metastatic Disease.
E. A. Danna, P. Sinha, M. Gilbert, V. K. Clements, B. A. Pulaski, and S. Ostrand-Rosenberg (2004)
Cancer Res. 64, 2205-2211
   Abstract »    Full Text »    PDF »
Expression Pattern of Chemokine Receptor 6 (CCR6) and CCR7 in Squamous Cell Carcinoma of the Head and Neck Identifies a Novel Metastatic Phenotype.
J. Wang, L. Xi, J. L. Hunt, W. Gooding, T. L. Whiteside, Z. Chen, T. E. Godfrey, and R. L. Ferris (2004)
Cancer Res. 64, 1861-1866
   Abstract »    Full Text »    PDF »
Gene expression profiles of primary breast tumors maintained in distant metastases.
B. Weigelt, A. M. Glas, L. F. A. Wessels, A. T. Witteveen, J. L. Peterse, and L. J. van't Veer (2003)
PNAS 100, 15901-15905
   Abstract »    Full Text »    PDF »
Determination of Clonality of Metastasis by Cell-Specific Color-Coded Fluorescent-Protein Imaging.
N. Yamamoto, M. Yang, P. Jiang, M. Xu, H. Tsuchiya, K. Tomita, A. R. Moossa, and R. M. Hoffman (2003)
Cancer Res. 63, 7785-7790
   Abstract »    Full Text »    PDF »
Fully Human Anti-Interleukin 8 Antibody Inhibits Tumor Growth in Orthotopic Bladder Cancer Xenografts via Down-Regulation of Matrix Metalloproteases and Nuclear Factor-{kappa}B.
B. M. Mian, C. P. N. Dinney, C. E. Bermejo, P. Sweeney, C. Tellez, X. D. Yang, J. M. Gudas, D. J. McConkey, and M. Bar-Eli (2003)
Clin. Cancer Res. 9, 3167-3175
   Abstract »    Full Text »    PDF »
Accurate molecular detection of melanoma nodal metastases: an assessment of multimarker assay specificity, sensitivity, and detection rate.
V Davids, S H Kidson, and G S Hanekom (2003)
Mol. Pathol. 56, 43-51
   Abstract »    Full Text »    PDF »
Fully Automated Three-Dimensional Tracking of Cancer Cells in Collagen Gels: Determination of Motility Phenotypes at the Cellular Level.
Z. N. Demou and L. V. McIntire (2002)
Cancer Res. 62, 5301-5307
   Abstract »    Full Text »    PDF »
An In Vitro Assay to Assess Uveal Melanoma Invasion across Endothelial and Basement Membrane Barriers.
J. K. L. Woodward, C. E. Nichols, I. G. Rennie, M. A. Parsons, A. K. Murray, and K. Sisley (2002)
Invest. Ophthalmol. Vis. Sci. 43, 1708-1714
   Abstract »    Full Text »    PDF »
Comparison of Accumulated Allele Loss between Primary Tumor and Lymph Node Metastasis in Stage II Non-small Cell Lung Carcinoma: Implications for the Timing of Lymph Node Metastasis and Prognostic Value.
E. Sasatomi, S. D. Finkelstein, J. D. Woods, A. Bakker, P. A. Swalsky, J. D. Luketich, H. C. Fernando, and S. A. Yousem (2002)
Cancer Res. 62, 2681-2689
   Abstract »    Full Text »    PDF »
Markers for Nodal Metastasis in Head and Neck Squamous Cell Cancer.
R. P. Takes, R. J. Baatenburg de Jong, M. J. R. C. Alles, C. A. Meeuwis, H. A. M. Marres, P. P. M. Knegt, G. B. de la Riviere, P. C. M. de Wilde, W. J. Mooi, J. Hermans, et al. (2002)
Arch Otolaryngol Head Neck Surg 128, 512-518
   Abstract »    Full Text »    PDF »
Early Placenta Insulin-like Growth Factor (pro-EPIL) Is Overexpressed and Secreted by c-erbB-2-positive Cells with High Invasion Potential.
B. Brandt, A. Roetger, J.-M. Bidart, J. Packeisen, K. Schier, J.-H. Mikesch, D. Kemming, W. Boecker, D. Yu, and H. Buerger (2002)
Cancer Res. 62, 1020-1024
   Abstract »    Full Text »    PDF »
Induction of c-Met Proto-Oncogene by Epstein-Barr Virus Latent Membrane Protein-1 and the Correlation with Cervical Lymph Node Metastasis of Nasopharyngeal Carcinoma.
T. Horikawa, T.-S. Sheen, H. Takeshita, H. Sato, M. Furukawa, and T. Yoshizaki (2001)
Am. J. Pathol. 159, 27-33
   Abstract »    Full Text »    PDF »
Differential Expression of Metastasis-Associated Genes in Papilla of Vater and Pancreatic Cancer Correlates With Disease Stage.
H. Friess, X.-Z. Guo, A. A. Tempia-Caliera, A. Fukuda, M. E. Martignoni, A. Zimmermann, M. Korc, and M. W. Buchler (2001)
J. Clin. Oncol. 19, 2422-2432
   Abstract »    Full Text »    PDF »
Heterogeneous Vascular Dependence of Tumor Cell Populations.
J. L. Yu, J. W. Rak, P. Carmeliet, A. Nagy, R. S. Kerbel, and B. L. Coomber (2001)
Am. J. Pathol. 158, 1325-1334
   Abstract »    Full Text »    PDF »
The role of angiogenesis in prostate and other urologic cancers: a review.
J. I. Izawa and C. P.N. Dinney (2001)
Can. Med. Assoc. J. 164, 662-670
   Abstract »    Full Text »    PDF »
Regulation of Neoplastic Angiogenesis.
I. J. Fidler (2000)
J Natl Cancer Inst Monographs 2000, 10-14
   Abstract »    Full Text »    PDF »
LRP-DIT, a Putative Endocytic Receptor Gene, Is Frequently Inactivated in Non-Small Cell Lung Cancer Cell Lines.
C.-X. Liu, S. Musco, N. M. Lisitsina, E. Forgacs, J. D. Minna, and N. A. Lisitsyn (2000)
Cancer Res. 60, 1961-1967
   Abstract »    Full Text »
Interleukin 8 Expression Regulates Tumorigenicity and Metastasis in Human Bladder Cancer.
K. Inoue, J. W. Slaton, S. J. Kim, P. Perrotte, B. Y. Eve, M. Bar-Eli, R. Radinsky, and C. P. N. Dinney (2000)
Cancer Res. 60, 2290-2299
   Abstract »    Full Text »
Evidence for Clonal Outgrowth of Androgen-independent Prostate Cancer Cells from Androgen-dependent Tumors through a Two-Step Process.
N. Craft, C. Chhor, C. Tran, A. Belldegrun, J. DeKernion, O. N. Witte, J. Said, R. E. Reiter, and C. L. Sawyers (1999)
Cancer Res. 59, 5030-5036
   Abstract »    Full Text »    PDF »
IFN-{gamma}- and Cell-to-Cell Contact-Dependent Cytotoxicity of Allograft-Induced Macrophages Against Syngeneic Tumor Cells and Cell Lines: An Application of Allografting to Cancer Treatment.
R. Yoshida, Y. Yoneda, M. Kuriyama, and T. Kubota (1999)
J. Immunol. 163, 148-154
   Abstract »    Full Text »    PDF »
Loss of Heterozygosity Accumulation in Primary Breast Carcinomas and Additionally in Corresponding Distant Metastases Is Associated with Poor Outcome.
M. Hampl, J. A. Hampl, G. Reiss, G. Schackert, H.-D. Saeger, and H. K. Schackert (1999)
Clin. Cancer Res. 5, 1417-1425
   Abstract »    Full Text »    PDF »
Reversible Tumorigenesis Induced by Deficiency of Vasodilator-Stimulated Phosphoprotein.
K. Liu, L. Li, P. E. Nisson, C. Gruber, J. Jessee, and S. N. Cohen (1999)
Mol. Cell. Biol. 19, 3696-3703
   Abstract »    Full Text »    PDF »
Comparative genomic hybridization, loss of heterozygosity, and DNA sequence analysis of single cells.
C. A. Klein, O. Schmidt-Kittler, J. A. Schardt, K. Pantel, M. R. Speicher, and G. Riethmuller (1999)
PNAS 96, 4494-4499
   Abstract »    Full Text »    PDF »
Severe Combined Immunodeficient-hu Model of Human Prostate Cancer Metastasis to Human Bone.
J. A. Nemeth, J. F. Harb, U. Barroso Jr., Z. He, D. J. Grignon, and M. L. Cher (1999)
Cancer Res. 59, 1987-1993
   Abstract »    Full Text »    PDF »
Selection of Potentially Metastatic Subpopulations Expressing c-erbB-2 from Breast Cancer Tissue by Use of an Extravasation Model.
A. Roetger, A. Merschjann, T. Dittmar, C. Jackisch, A. Barnekow, and B. Brandt (1998)
Am. J. Pathol. 153, 1797-1806
   Abstract »    Full Text »    PDF »
Prognostic Significance of PCNA Expression in Laryngeal Cancer.
S. Sarac, A. Ayhan, A. S. Hosal, and S. Kaya (1998)
Arch Otolaryngol Head Neck Surg 124, 1321-1324
   Abstract »    Full Text »    PDF »
Association Between the Rat Homologue of CO-029, a Metastasis-associated Tetraspanin Molecule and Consumption Coagulopathy.
C. Claas, S. Seiter, A. Claas, L. Savelyeva, M. Schwab, and M. Zoller (1998)
J. Cell Biol. 141, 267-280
   Abstract »    Full Text »    PDF »
Overexpressed human CD44s promotes lung colonization during micrometastasis of murine fibrosarcoma cells: Facilitated retention in the lung vasculature.
P. Kogerman, M.-S. Sy, and L. A. Culp (1997)
PNAS 94, 13233-13238
   Abstract »    Full Text »    PDF »
Morphologic Characteristics of the Interaction Between Normal Cytotrophoblasts and Their Malignant Counterpart in the Development of Trophoblastic Neoplasia.
R. Goshen, H. Schreck, D. Komitowski, S. Karnaoukhova, B. Gonik, D. Weinstein, N. de Groot, and A. Hochberg (1996)
Reproductive Sciences 3, 209-215
   Abstract »    PDF »
Hepatic Flow Scintigraphy in Evaluation of Hepatic Metastases in Patients With Gastrointestinal Malignancy.
M. Huguier, S. Maheswari, P. Toussaint, S. Houry, S. Mauban, and B. Mensch (1993)
Arch Surg 128, 1057-1059
   Abstract »    PDF »
Carcinoembryonic Antigen Enhances Metastatic Potential of Human Colorectal Carcinoma.
R. B. Hostetter, D. E. Campbell, K. Chi, S. Kerckhoff, K. R. Cleary, S. Ullrich, P. Thomas, and J. M. Jessup (1990)
Arch Surg 125, 300-304
   Abstract »    PDF »
Identification of a chromosome 18q gene that is altered in colorectal cancers.
E. Fearon, K. Cho, J. Nigro, S. Kern, J. Simons, J. Ruppert, Hamilton SR, A. Preisinger, G Thomas, K. Kinzler, et al. (1990)
Science 247, 49-56
   Abstract »    PDF »
Dynamic heterogeneity: rapid generation of metastatic variants in mouse B16 melanoma cells.
R. Hill, A. Chambers, V Ling, and J. Harris (1984)
Science 224, 998-1001
   Abstract »    PDF »
Chemical Carcinogenesis: Hepatocyte Nodules with a Special Phenotype As a Common Step at the Crossroads.
E. Farber, L. C. Eriksson, M. W. Roomi, R. G. Cameron, and M. A. Hayes (1984)
Toxicol Pathol 12, 288-290
   Abstract »    PDF »
Biotinated probe containing a long-terminal repeat hybridized to a mouse colon tumor and normal tissue.
M. Royston and L. Augenlicht (1983)
Science 222, 1339-1341
   Abstract »    PDF »



To Advertise     Find Products


Science. ISSN 0036-8075 (print), 1095-9203 (online)