Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 10 September 1982:
Vol. 217. no. 4564, pp. 1048 - 1050
DOI: 10.1126/science.7051285
Prev | Table of Contents | Next

Articles

Science, Vol 217, Issue 4564, 1048-1050
Copyright © 1982 by American Association for the Advancement of Science

articles

Plasmodium falciparum gametocytes from culture in vitro develop to sporozoites that are infectious to primates

CC Campbell, WE Collins, P Nguyen-Dinh, A Barber, and Broderson JR

Gametocytes of two strains of the human malaria parasite Plasmodium falciparum have been produced in high density by means of a continuous-flow cultivation system. The gametocytes of these two strains infected a mean of 36 percent and 71 percent, respectively, of Anopheles freeborni mosquitoes that fed on a suspension of red blood cells containing the culture gametocytes. Sporozoites harvested from the infected mosquito salivary glands were infective to the chimpanzee (Pan troglodytes) and the owl monkey (Aotus trivirgatus).


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
PRELIMINARY OBSERVATIONS ON THE EFFICACY OF A RECOMBINANT MULTISTAGE PLASMODIUM FALCIPARUM VACCINE IN AOTUS NANCYMAI MONKEYS.
W. E. COLLINS, G. G. GALLAND, J. W. BARNWELL, V. UDHAYAKUMAR, J. S. SULLIVAN, D. NACE, J. E. TONGREN, T. WILLIAMS, J. ROBERTS, Y. P. SHI, et al. (2005)
Am J Trop Med Hyg 73, 686-693
   Abstract »    Full Text »    PDF »
Rationale and plans for developing a non-replicating, metabolically active, radiation-attenuated Plasmodium falciparum sporozoite vaccine.
T. C. Luke and S. L. Hoffman (2003)
J. Exp. Biol. 206, 3803-3808
   Abstract »    Full Text »    PDF »
Genetic analysis of the human malaria parasite Plasmodium falciparum.
D Walliker, I. Quakyi, T. Wellems, T. McCutchan, A Szarfman, W. London, L. Corcoran, T. Burkot, and R Carter (1987)
Science 236, 1661-1666
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)