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Science 27 August 1982:
Vol. 217. no. 4562, pp. 851 - 853
DOI: 10.1126/science.7048529
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Articles

Science, Vol 217, Issue 4562, 851-853
Copyright © 1982 by American Association for the Advancement of Science

articles

Anomalous patterns in cultured cell monolayers

EM Adler, LJ Flunk, JM Mullin, and A Kleinzeller

Gridlike patterns of differing cell density were observed in evenly seeded cell monolayers. Such patterns were obtained in five of six cell lines tested, suggesting widespread occurrence. The mechanism appears to involve small, transient temperature changes related to incubator tray structure. The very short time course of appearance of the patterns implicates attachment rather than growth as the critically affected factor. Impaired adhesion or directed sedimentation resulting from thermally induced microcurrents in the medium are the two most likely mechanisms.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)