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Science 27 August 1982:
Vol. 217. no. 4562, pp. 848 - 851
DOI: 10.1126/science.6285474
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Articles

Science, Vol 217, Issue 4562, 848-851
Copyright © 1982 by American Association for the Advancement of Science

articles

Significance of tissue myo-inositol concentrations in metabolic regulation in nerve

DA Simmons, AI Winegrad, and DB Martin

Approximately 25 percent of resting energy utilization in isolated nerve endoneurium is inhibited by medium containing defatted albumin and selectively restored by arachidonic acid but is unaffected by indomethacin or nordihydroguaiaretic acid. The same component of energy utilization is inhibited by small decreases in endoneurial myo-inositol, which decrease incorporation of carbon-14-labeled arachidonic acid into phosphatidylinositol. The fraction of the resting oxygen uptake inhibited by ouabain is decreased 40 to 50 percent by a reduced tissue myo-inositol concentration or by defatted albumin. Metabolic regulation by rapid, basal phosphatidylinositol turnover is dependent on the maintenance of normal tissue myoinositol concentrations.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Decreased oxidation of labeled glucose by dissociated brain cells in the presence of fetal bovine serum.
J. Tildon and J. Stevenson (1984)
Science 224, 903-904
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