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Science 27 August 1982:
Vol. 217. no. 4562, pp. 845 - 848
DOI: 10.1126/science.6285473
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Articles

Science, Vol 217, Issue 4562, 845-848
Copyright © 1982 by American Association for the Advancement of Science

articles

Endotoxin-stimulated opioid peptide secretion: two secretory pools and feedback control in vivo

DB Carr, R Bergland, A Hamilton, H Blume, N Kasting, M Arnold, JB Martin, and M Rosenblatt

Small doses of endotoxin evoked a dramatic biphasic response of opioid peptide secretion into blood in sheep. The first phase began within minutes and coincided with a brief hypertensive response to endotoxin well before the appearance of fever or hypotension. The ratio of beta-endorphin to beta-lipotropin fell abruptly at the onset of the second phase of release, suggesting early depletion of a pool rich in beta-endorphin and subsequent emergence of a pool rich in unprocessed precursor. The concentration of cerebrospinal fluid opioids increased tenfold during the second phase. Naloxone administration augmented endotoxin-induced opioid secretion in both early and late phases, suggesting a short-loop feedback regulation of stress-induced endorphin secretion.


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