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Science 20 August 1982:
Vol. 217. no. 4561, pp. 747 - 750
DOI: 10.1126/science.7100922
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Articles

Science, Vol 217, Issue 4561, 747-750
Copyright © 1982 by American Association for the Advancement of Science

articles

Mice regrow the tips of their foretoes

RB Borgens

Mice will replace the tip of a foretoe when it is amputated distal to the last interphalangeal joint. Amputation of the digit more proximal to the joint does not result in regrowth of the foretoe. Though this growth shares certain similarities with the epimorphic regeneration of amphibian limbs, the two processes are not the same. The regrowth reported here in mice is probably similar to the scattered clinical reports of fingertips regeneration in children, and presents a model system with which to explore the controls of wound healing and tissue reconstruction in mammals.


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Advances in signaling in vertebrate regeneration as a prelude to regenerative medicine.
C. L. Stoick-Cooper, R. T. Moon, and G. Weidinger (2007)
Genes & Dev. 21, 1292-1315
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Digit regeneration is regulated by Msx1 and BMP4 in fetal mice.
M. Han, X. Yang, J. E. Farrington, and K. Muneoka (2003)
Development 130, 5123-5132
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Digit tip regeneration correlates with regions of Msx1 (Hox 7) expression in fetal and newborn mice.
A. Reginelli, Y. Wang, D Sassoon, and K Muneoka (1995)
Development 121, 1065-1076
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