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Science 13 August 1982:
Vol. 217. no. 4560, pp. 652 - 655
DOI: 10.1126/science.7089586
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Articles

Science, Vol 217, Issue 4560, 652-655
Copyright © 1982 by American Association for the Advancement of Science

articles

Force-Sensitive Interneurons in the Spinal Cord of the Cat

CL Cleland, WZ Rymer, and FR Edwards

The input-output properties of interneurons mediating spinal reflexes were investigated by extracellularly recording the res\ ponse of interneurons to excitation from muscle receptors in the ankle extensor muscles of decerebrated, spinal cats. A popu\ lation ofinterneurons in the intermediate region ofthe spinal cord is potently excited by increases in muscle force. Unlike \ the discharge of Golgi tendon organs, which accurately encodes moment-to-moment variations in the force of a single muscle, \ the discharge of these interneurons depends in a dynamic and usually nonlinear way on the force in several muscles. Powerful\ input from unidentified mechanoreceptors in muscle, presumably free nerve endings, is at least partly responsible for these\ properties. These force-sensitive interneurons are more likely to mediate clasp knife-type inhibition than simple negative \ force feedback.


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