Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 6 August 1982:
Vol. 217. no. 4559, pp. 557 - 559
DOI: 10.1126/science.7089582
Prev | Table of Contents

Articles

Science, Vol 217, Issue 4559, 557-559
Copyright © 1982 by American Association for the Advancement of Science

articles

Adrenal medullary enkephalin-like peptides may mediate opioid stress analgesia

JW Lewis, MG Tordoff, JE Sherman, and JC Liebeskind

Different patterns of fact shock activate opioid and nonopioid mechanisms of stress analgesia in the rat. Opioid, but not nonopioid, stress analgesia is reduced by adrenal demedullation and denervation and is potentiated by reserpine, a drug known to increase concentrations of adrenal medullary enkephalin-like peptides. It is suggested that adrenal enkephalins mediate opioid stress analgesia.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Intrinsic mechanisms of pain inhibition: activation by stress.
G. Terman, Y Shavit, J. Lewis, J. Cannon, and J. Liebeskind (1984)
Science 226, 1270-1277
   Abstract »    PDF »
Impulse activity differentially regulates [Leu]enkephalin and catecholamine characters in the adrenal medulla.
E. LaGamma, J. Adler, and I. Black (1984)
Science 224, 1102-1104
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)