Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 6 August 1982:
Vol. 217. no. 4559, pp. 555 - 557
DOI: 10.1126/science.6178165
Prev | Table of Contents | Next

Articles

Science, Vol 217, Issue 4559, 555-557
Copyright © 1982 by American Association for the Advancement of Science

articles

Presynaptic location and axonal transport of beta 1-adrenoreceptors in the rat brain

BE Levin

Interruption of the ascending noradrenergic neurons of the locus coeruleus in the rat forebrain with 6-hydroxydopamine produced a progressive accumulation, proximal to the lesion, of tritiated dihydroalprenolol binding activity over 2 days. This accumulation could be blocked by interrupting the neurons closer to their cell bodies. Competitive binding studies with the beta 2 agonist Zinterol suggested that the accumulated beta-receptors were primarily of the beta 1 subtype. These results suggest that, in the rat brain, some beta 1-adrenoreceptors are located in presynaptic, noradrenergic locus coeruleus neurons and are transported in their axons.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Behavioral effects of progesterone associated with rapid modulation of oxytocin receptors.
M Schumacher, H Coirini, D. Pfaff, and B. McEwen (1990)
Science 250, 691-694
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)