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Science 30 July 1982:
Vol. 217. no. 4558, pp. 448 - 450
DOI: 10.1126/science.217.4558.448
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Articles

Changes in the Cell Membranes of the Bullfrog Gastric Mucosa with Acid Secretion

CHRIS CLAUSEN 1, TERRY E. MACHEN 2, and JARED M. DIAMOND 3

1 Department of Physiology and Biophysics, State University of New York, Stony Brook 11794
2 Department of Physiology and Anatomy, University of California, Berkeley 94720
3 Department of Physiology, University of California Medical Center, Los Angeles 90024

The effective area, resistance, and configuration of the apical and basolateral cell membranes of the bullfrog gastric mucosa were studied as a function of acid secretion rate, by alternating-current impedance methods. The drop in transepithelial resistance with acid secretion is attributed to the great increase in apical membrane area (hence conductance) associated with tubulovesicles. There is no evidence of a change in basolateral membrane resistance or of apical membrane premeability per unit area.

Submitted on October 27, 1981
Revised on March 30, 1982


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Activation of apical chloride channels in the gastric oxyntic cell.
J. Demarest, D. Loo, and G Sachs (1989)
Science 245, 402-404
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Science. ISSN 0036-8075 (print), 1095-9203 (online)