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Science 16 July 1982:
Vol. 217. no. 4556, pp. 259 - 261
DOI: 10.1126/science.7046048
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Articles

Science, Vol 217, Issue 4556, 259-261
Copyright © 1982 by American Association for the Advancement of Science

articles

Transplantation of Leukemic Bone Marrow Treated with Cytotoxic Antileukemic Antibodies and Complement

Michael E. Trigg, David G. Poplack

The ability of antiserum against murine L1210 leukemia to remove residual leukemia cells from murine bone marrow was investigated. Leukemic marrow was treated in vitro with antiserum and complement and used to hematologically reconstitute mice that had been irradiated with doses lethal to bone marrow. Following infusion of treated leukemic marrow, normal marrow returned without evidence of leukemia. More than 90 percent of the animals have survived for 11 months without untoward effects, suggesting that the technique may be of use in the treatment of acute leukemia in humans.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)