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Science 16 July 1982:
Vol. 217. no. 4556, pp. 254 - 257
DOI: 10.1126/science.6178159
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Articles

Science, Vol 217, Issue 4556, 254-257
Copyright © 1982 by American Association for the Advancement of Science

articles

Antigenic diversity in the human malaria parasite Plasmodium falciparum

JS McBride, D Walliker, and G Morgan

Monoclonal antibodies against blood forms of Plasmodium falciparum were used to demonstrate considerable antigenic diversity in this species. Different isolates were distinguished by their ability to react with certain antibodies, and most of the antibodies reacted specifically with merozoites, schizonts, or both. The distribution of different antigenic types appeared not to be related to geographic origin. Serological typing with monoclonal antibodies extends the range of methods for identification of different strains of this malaria parasite.


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