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Science 9 July 1982:
Vol. 217. no. 4555, pp. 151 - 153
DOI: 10.1126/science.6211766
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Articles

Science, Vol 217, Issue 4555, 151-153
Copyright © 1982 by American Association for the Advancement of Science

articles

Gut reactions of radioactive nitrite after intratracheal administration in mice

Thayer JR, JH Chasko, LA Swartz, and NJ Parks

Intratracheal administration to mice of radioactive nitrite labeled with nitrogen-13 (13NO2-) (half-life, 9.96 minutes) in dosages that do not cause pharmacological perturbation reveals that oxidative and reductive reactions occur in different organs. Oxidation of 13NO2- to radioactive nitrate (13NO3-) predominates in the blood and liver. Reduction of 13NO2- occurs in those mice that harbor intestinal microflora; this reduction does not occur in germ-free mice. The intestinal reduction products include ammonium, glutamate, glutamine, and urea. With a detection limit of about 0.01 percent of the instilled nitrogen-13, no labeled nitrosamines were detected within 30 minutes. Reduced nitrogen-13 is transported out of the intensive into the circulatory system and appears in the urine along with 13NO3-. The biological half-period for 13NO2- destruction is about 7 minutes, and both oxidation and reduction products are formed.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Acute Blood Pressure Lowering, Vasoprotective, and Antiplatelet Properties of Dietary Nitrate via Bioconversion to Nitrite.
A. J. Webb, N. Patel, S. Loukogeorgakis, M. Okorie, Z. Aboud, S. Misra, R. Rashid, P. Miall, J. Deanfield, N. Benjamin, et al. (2008)
Hypertension 51, 784-790
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