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Science 2 July 1982:
Vol. 217. no. 4554, pp. 77 - 79
DOI: 10.1126/science.7046046
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Articles

Science, Vol 217, Issue 4554, 77-79
Copyright © 1982 by American Association for the Advancement of Science

articles

Purinergic regulation of food intake

AS Levine and JE Morley

Inosine peripherally administered to rats markedly suppressed spontaneous food intake and food intake induced by diazepam, muscimol, insulin, and food deprivation. The purines 2-deoxyguanosine and 2-deoxyinosine also suppressed food deprivation-induced feeding, whereas 7-methylinosine, which does not bind to the benzodiazepine binding site in vitro, had no effect on food intake when compared with controls. These results suggest that purines may represent endogenous substances that regulate food intake through interactions with the benzodiazepine receptor.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Physiology and Pathophysiology of Purinergic Neurotransmission.
G. Burnstock (2007)
Physiol Rev 87, 659-797
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