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Science 2 July 1982:
Vol. 217. no. 4554, pp. 62 - 63
DOI: 10.1126/science.6283632
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Articles

Science, Vol 217, Issue 4554, 62-63
Copyright © 1982 by American Association for the Advancement of Science

articles

Corticotropin-releasing factor stimulates secretion of melanocyte-stimulating hormone from the rat pituitary

L Proulx-Ferland, F Labrie, D Dumont, J Cote, DH Coy, and J Sveiraf

Administration of synthetic ovine corticotropin-releasing factor led to rapid, parallel increases in adrenocorticotropin and alpha-melanocyte-stimulating hormone concentrations in rat plasma. Prior treatment with dexamethasone almost completely blocked the adrenocorticotropin response but not the increase in melanocyte-stimulating hormone. These data demonstrate that corticotropin-releasing factor is a potent stimulator not only of adrenocorticotropin secretion from the corticotrophs of the anterior pituitary gland but also of peptide secretion from the intermediate lobe. Such data suggest that melanocyte-stimulating hormone and beta-endorphin play a role in the physiological response to stress.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Corticotropin-releasing factor receptors in rat forebrain: autoradiographic identification.
E. De Souza, M. Perrin, T. Insel, J Rivier, W. Vale, and M. Kuhar (1984)
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