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Science 25 June 1982:
Vol. 216. no. 4553, pp. 1425 - 1427
DOI: 10.1126/science.7089531
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Articles

Science, Vol 216, Issue 4553, 1425-1427
Copyright © 1982 by American Association for the Advancement of Science

articles

Reduced leucine-enkephalin--like immunoreactive substance in hamster basal ganglia after long-term ethanol exposure

K Blum, AH Briggs, SF Elston, L DeLallo, PJ Sheridan, and M Sar

Golden Syrian hamsters were placed individually in cages with three drinking bottles--one empty, one containing water, and the third containing water and ethanol. Control hamsters received water only. After 1 year the experimental hamsters showed a significantly lower concentration of leucine-enkephalin-like immunoreactive substance in the basal ganglia than the control hamsters. This finding indicates that the action of ethanol involves endogenous peptidyl opiates.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)