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Science 28 May 1982:
Vol. 216. no. 4549, pp. 1007 - 1008
DOI: 10.1126/science.6281886
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Articles

Science, Vol 216, Issue 4549, 1007-1008
Copyright © 1982 by American Association for the Advancement of Science

articles

Corticotropin-releasing factor stimulates accumulation of adenosine 3', 5'-monophosphate in rat pituitary corticotrophs

F Labrie, R Veilleux, G Lefevre, DH Coy, J Sueiras-Diaz, and AV Schally

The presence of synthetic ovine corticotropin-releasing factor leads to a rapid and marked stimulation of adenosine 3', 5'-monophosphate accumulation in an enriched population of rat pituitary corticotrophs in primary culture. The increase, observed as early as 60 seconds after the addition of corticotropin-releasing factor, suggests that changes in the intracellular concentration of the cyclic nucleotide coincide with or precede the secretion of adrenocorticotropic hormone in response to corticotropin-releasing factor.


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