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Science 28 May 1982:
Vol. 216. no. 4549, pp. 1001 - 1003
DOI: 10.1126/science.6281884
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Articles

Science, Vol 216, Issue 4549, 1001-1003
Copyright © 1982 by American Association for the Advancement of Science

articles

Spectral character of sunlight modulates photosynthesis of previtamin D3 and its photoisomers in human skin

JA MacLaughlin, RR Anderson, and MF Holick

The photosynthesis of previtamin D3 from 7-dehydrocholesterol in human skin was determined after exposure to narrow-band radiation or simulated solar radiation. The optimum wavelengths for the production of previtamin D3 were determined to be between 295 and 300 nanometers. When human skin was exposed to 295-nanometer radiation, up to 65 percent of the original 7-dehydrocholesterol content was converted to previtamin D3. In comparison, when adjacent skin was exposed to simulated solar radiation, the maximum formation of previtamin D3 was about 20 percent. Major differences in the formation of lumisterol3, and tachysterol3 from previtamin D3 were also observed. It is concluded that the spectral character of natural sunlight has a profound effect on the photochemistry of 7-dehydrocholesterol in human skin.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Sun and Sun Beds: Inducers of Vitamin D and Skin Cancer.
E. CICARMA, A. C. POROJNICU, Z. LAGUNOVA, A. DAHLBACK, A. JUZENIENE, and J. MOAN (2009)
Anticancer Res 29, 3495-3500
   Abstract »    Full Text »    PDF »
Solar Radiation, Vitamin D and Cancer Incidence and Mortality in Norway.
J. MOAN, A. DAHLBACK, Z. LAGUNOVA, E. CICARMA, and A. C. POROJNICU (2009)
Anticancer Res 29, 3501-3509
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Review and meta-analysis on vitamin D receptor polymorphisms and cancer risk.
S. Raimondi, H. Johansson, P. Maisonneuve, and S. Gandini (2009)
Carcinogenesis 30, 1170-1180
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From the Cover: Addressing the health benefits and risks, involving vitamin D or skin cancer, of increased sun exposure.
J. Moan, A. C. Porojnicu, A. Dahlback, and R. B. Setlow (2008)
PNAS 105, 668-673
   Abstract »    Full Text »    PDF »
SOLAR Ultraviolet Radiation AND Vitamin D: A Historical Perspective.
K. Rajakumar, S. L. Greenspan, S. B. Thomas, and M. F. Holick (2007)
Am J Public Health 97, 1746-1754
   Abstract »    Full Text »    PDF »
High Prevalence of Vitamin D Inadequacy and Implications for Health.
M. F. Holick (2006)
Mayo Clin. Proc. 81, 353-373
   Abstract »    Full Text »    PDF »
Body Fat Content and 25-Hydroxyvitamin D Levels in Healthy Women.
S. Arunabh, S. Pollack, J. Yeh, and J. F. Aloia (2003)
J. Clin. Endocrinol. Metab. 88, 157-161
   Abstract »    Full Text »    PDF »
A Liposomal Model That Mimics the Cutaneous Production of Vitamin D3. STUDIES OF THE MECHANISM OF THE MEMBRANE-ENHANCED THERMAL ISOMERIZATION OF PREVITAMIN D3 TO VITAMIN D3.
X. Q. Tian and M. F. Holick (1999)
J. Biol. Chem. 274, 4174-4179
   Abstract »    Full Text »    PDF »
Catalyzed Thermal Isomerization between Previtamin D[IMAGE]and Vitamin D[IMAGE]via [IMAGE]-Cyclodextrin Complexation.
X. Q. Tian and M. F. Holick (1995)
J. Biol. Chem. 270, 8706-8711
   Abstract »    Full Text »    PDF »
Photoprotection and the Vitamin D Status of the Elderly: A Concern for Dermatologists.
J. H. Prystowsky (1988)
Arch Dermatol 124, 1844-1848
   Abstract »    PDF »
Skin as the Site of Vitamin D Synthesis and Target Tissue for 1,25-Dihydroxyvitamin D3: Use of Calcitriol (1,25-Dihydroxyvitamin D3) for Treatment of Psoriasis.
M. F. Holick, E. Smith, and S. Pincus (1987)
Arch Dermatol 123, 1677-1683a
   Abstract »    PDF »


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