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Science 21 May 1982:
Vol. 216. no. 4548, pp. 897 - 899
DOI: 10.1126/science.7079743
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Articles

Science, Vol 216, Issue 4548, 897-899
Copyright © 1982 by American Association for the Advancement of Science

articles

Nerve fiber growth on defined hydrogel substrates

ST Carbonetto, MM Gruver, and DC Turner

Cultured neurons become attached to hydrogel substrates prepared from 2-hydroxyethylmethacrylate but grow few nerve fibers unless fibronectin, collagen, or nerve growth factor is incorporated into the hydrogel. Antibodies to fibronectin inhibit nerve fiber growth on hydrogels containing fibronectin, which suggests that growing neurons interact directly with proteins trapped in the hydrogel. The adhesive requirements for attachment of neurons appear distinct and possibly less specific than those for fiber growth. Defined hydrogel substrates offer a controlled method for analyzing complex substrates that support nerve fiber growth and neuronal differentiation.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Nerve Growth Factor Enhances Nerve Regeneration through Fibronectin Grafts.
I. H. WHITWORTH, R. A. BROWN, C. J. DORE, P. ANAND, C. J. GREEN, and G. TERENGHI (1996)
J Hand Surg Eur Vol. 21, 514-522
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