Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Science 21 May 1982:
Vol. 216. no. 4548, pp. 890 - 892
DOI: 10.1126/science.7079742

Articles

Science, Vol 216, Issue 4548, 890-892
Copyright © 1982 by American Association for the Advancement of Science


articles

Neurons in the rat dentate gyrus granular layer substantially increase during juvenile and adult life

SA Bayer, JW Yackel, and PS Puri

Volumetric estimates of the total number of granule cells in rats 30, 120, 200, and 365 days old increase linearly by approximately 35 to 43 percent between 1 month and 1 year. Total volume of the granular layer also grows linearly during that time. These results demonstrate a numerical increase in a neuronal population during adulthood in the mammalian brain.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
ClC3 Is a Critical Regulator of the Cell Cycle in Normal and Malignant Glial Cells.
C. W. Habela, M. L. Olsen, and H. Sontheimer (2008)
J. Neurosci. 28, 9205-9217
   Abstract »    Full Text »    PDF »
Understanding the Regulation and Function of Adult Neurogenesis: Contribution from an Insect Model, the House Cricket.
M. Cayre, S. Scotto-Lomassese, J. Malaterre, C. Strambi, and A. Strambi (2007)
Chem Senses 32, 385-395
   Abstract »    Full Text »    PDF »
A carbohydrate-binding protein, Galectin-1, promotes proliferation of adult neural stem cells.
M. Sakaguchi, T. Shingo, T. Shimazaki, H. J. Okano, M. Shiwa, S. Ishibashi, H. Oguro, M. Ninomiya, T. Kadoya, H. Horie, et al. (2006)
PNAS 103, 7112-7117
   Abstract »    Full Text »    PDF »
Neuronal Differentiation in the Adult Hippocampus Recapitulates Embryonic Development.
M. S. Esposito, V. C. Piatti, D. A. Laplagne, N. A. Morgenstern, C. C. Ferrari, F. J. Pitossi, and A. F. Schinder (2005)
J. Neurosci. 25, 10074-10086
   Abstract »    Full Text »    PDF »
Male-specific Volume Expansion of the Human Hippocampus during Adolescence.
M. Suzuki, H. Hagino, S. Nohara, S.-Y. Zhou, Y. Kawasaki, T. Takahashi, M. Matsui, H. Seto, T. Ono, and M. Kurachi (2005)
Cereb Cortex 15, 187-193
   Abstract »    Full Text »    PDF »
Neurogenic Effect of {beta}-Amyloid Peptide in the Development of Neural Stem Cells.
M. A. Lopez-Toledano and M. L. Shelanski (2004)
J. Neurosci. 24, 5439-5444
   Abstract »    Full Text »    PDF »
Selective vulnerability of dentate granule cells prior to amyloid deposition in PDAPP mice: Digital morphometric analyses.
C.-C. Wu, F. Chawla, D. Games, R. E. Rydel, S. Freedman, D. Schenk, W. G. Young, J. H. Morrison, and F. E. Bloom (2004)
PNAS 101, 7141-7146
   Abstract »    Full Text »    PDF »
Binding Sites of {gamma}-Secretase Inhibitors in Rodent Brain: Distribution, Postnatal Development, and Effect of Deafferentation.
X.-X. Yan, T. Li, C. M. Rominger, S. R. Prakash, P. C. Wong, R. E. Olson, R. Zaczek, and Y.-W. Li (2004)
J. Neurosci. 24, 2942-2952
   Abstract »    Full Text »    PDF »
Suppression of Adult Neurogenesis Impairs Olfactory Learning and Memory in an Adult Insect.
S. Scotto-Lomassese, C. Strambi, A. Strambi, A. Aouane, R. Augier, G. Rougon, and M. Cayre (2003)
J. Neurosci. 23, 9289-9296
   Abstract »    Full Text »    PDF »
Misguided Axonal Projections, Neural Cell Adhesion Molecule 180 mRNA Upregulation, and Altered Behavior in Mice Deficient for the Close Homolog of L1.
M. Montag-Sallaz, M. Schachner, and D. Montag (2002)
Mol. Cell. Biol. 22, 7967-7981
   Abstract »    Full Text »    PDF »
Development of symptoms of tobacco dependence in youths: 30 month follow up data from the DANDY study.
J R DiFranza, J A Savageau, N A Rigotti, K Fletcher, J K Ockene, A D McNeill, M Coleman, and C Wood (2002)
Tob. Control 11, 228-235
   Abstract »    Full Text »    PDF »
Effects of Reversible Inactivation of the Neonatal Ventral Hippocampus on Behavior in the Adult Rat.
B. K. Lipska, N. D. Halim, P. N. Segal, and D. R. Weinberger (2002)
J. Neurosci. 22, 2835-2842
   Abstract »    Full Text »    PDF »
Functional and molecular analysis of transient voltage-dependent K+ currents in rat hippocampal granule cells.
V. Riazanski, A. Becker, J. Chen, D. Sochivko, A. Lie, O. D Wiestler, C. E Elger, and H. Beck (2001)
J. Physiol. 537, 391-406
   Abstract »    Full Text »    PDF »
Subunit Heterogeneity of Cytoplasmic Dynein: Differential Expression of 14 kDa Dynein Light Chains in Rat Hippocampus.
J.-Z. Chuang, T. A. Milner, and C.-H. Sung (2001)
J. Neurosci. 21, 5501-5512
   Abstract »    Full Text »    PDF »
The generation, migration, and differentiation of olfactory neurons in the adult primate brain.
D. R. Kornack and P. Rakic (2001)
PNAS 98, 4752-4757
   Abstract »    Full Text »    PDF »
Adult Spinal Cord Stem Cells Generate Neurons after Transplantation in the Adult Dentate Gyrus.
L. S. Shihabuddin, P. J. Horner, J. Ray, and F. H. Gage (2000)
J. Neurosci. 20, 8727-8735
   Abstract »    Full Text »    PDF »
Stem Cells and Neuronal Progenitors and Their Diversity in the CNS: Are Time and Place Important?.
F. M. Vaccarino (2000)
Neuroscientist 6, 338-352
   Abstract »    PDF »
Neurogenesis and Gliogenesis in the Postischemic Brain.
J. Liu, R. Bernabeu, A. Lu, and F. R. Sharp (2000)
Neuroscientist 6, 362-370
   Abstract »    PDF »
Importance of newly generated neurons in the adult olfactory bulb for odor discrimination.
G. Gheusi, H. Cremer, H. McLean, G. Chazal, J.-D. Vincent, and P.-M. Lledo (2000)
PNAS 97, 1823-1828
   Abstract »    Full Text »    PDF »
Human Neuronal gamma -Aminobutyric AcidA Receptors: Coordinated Subunit mRNA Expression and Functional Correlates in Individual Dentate Granule Cells.
A. R. Brooks-Kayal, M. D. Shumate, H. Jin, D. D. Lin, T. Y. Rikhter, K. L. Holloway, and D. A. Coulter (1999)
J. Neurosci. 19, 8312-8318
   Abstract »    Full Text »    PDF »
Continuation of neurogenesis in the hippocampus of the adult macaque monkey.
D. R. Kornack and P. Rakic (1999)
PNAS 96, 5768-5773
   Abstract »    Full Text »    PDF »
Neurogenesis, cell death and regeneration in the adult gymnotiform brain.
G. Zupanc (1999)
J. Exp. Biol. 202, 1435-1446
   Abstract »    PDF »
Increased Neurogenesis in the Dentate Gyrus After Transient Global Ischemia in Gerbils.
J. Liu, K. Solway, R. O. Messing, and F. R. Sharp (1998)
J. Neurosci. 18, 7768-7778
   Abstract »    Full Text »    PDF »
Experience-Induced Neurogenesis in the Senescent Dentate Gyrus.
G. Kempermann, H. G. Kuhn, and F. H. Gage (1998)
J. Neurosci. 18, 3206-3212
   Abstract »    Full Text »    PDF »
Bcl-2 Protein as a Marker of Neuronal Immaturity in Postnatal Primate Brain.
P. J. Bernier and A. Parent (1998)
J. Neurosci. 18, 2486-2497
   Abstract »    Full Text »    PDF »
Olfactory Bulb Recovery after Early Sensory Deprivation.
D. M. Cummings, H. E. Henning, and P. C. Brunjes (1997)
J. Neurosci. 17, 7433-7440
   Abstract »    Full Text »    PDF »
Genetic influence on neurogenesis in the dentate gyrus of adult mice.
G. Kempermann, H. G. Kuhn, and F. H. Gage (1997)
PNAS 94, 10409-10414
   Abstract »    Full Text »    PDF »
Dentate Granule Cell Neurogenesis Is Increased by Seizures and Contributes to Aberrant Network Reorganization in the Adult Rat Hippocampus.
J. M. Parent, T. W. Yu, R. T. Leibowitz, D. H. Geschwind, R. S. Sloviter, and D. H. Lowenstein (1997)
J. Neurosci. 17, 3727-3738
   Abstract »    Full Text »    PDF »
Multipotent CNS Stem Cells Are Present in the Adult Mammalian Spinal Cord and Ventricular Neuroaxis.
S. Weiss, C. Dunne, J. Hewson, C. Wohl, M. Wheatley, A. C. Peterson, and B. A. Reynolds (1996)
J. Neurosci. 16, 7599-7609
   Abstract »    Full Text »    PDF »
Review : Neuronal Precursor Cells and Neurogenesis in the Adult Forebrain.
S. A. Goldman (1995)
Neuroscientist 1, 338-350
   Abstract »    PDF »
Long-distance neuronal migration in the adult mammalian brain.
C Lois and A Alvarez-Buylla (1994)
Science 264, 1145-1148
   Abstract »    PDF »
Limits of neurogenesis in primates.
P Rakic (1985)
Science 227, 1054-1056
   Abstract »    PDF »
Neurons generated in the adult brain are recruited into functional circuits.
J. Paton and F. Nottebohm (1984)
Science 225, 1046-1048
   Abstract »    PDF »



To Advertise     Find Products


Science. ISSN 0036-8075 (print), 1095-9203 (online)