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Science 14 May 1982:
Vol. 216. no. 4547, pp. 737 - 739
DOI: 10.1126/science.7079733
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Articles

Science, Vol 216, Issue 4547, 737-739
Copyright © 1982 by American Association for the Advancement of Science

articles

Secretion of newly taken-up ascorbic acid by adrenomedullary chromaffin cells

AJ Daniels, G Dean, OH Viveros, and EJ Diliberto Jr

Primary cultures of bovine adrenomedullary cells accumulate carbon-14-labeled ascorbic acid through a saturable and energy-dependent process. The newly taken-up ascorbate is released concomitantly with catecholamines upon stimulation of chromaffin cell secretion. The release of ascorbate is Ca2+-dependent and mediated through activation of nicotinic receptors. These results indicate that exogenous ascorbate taken up into chromaffin cells is incorporated in situ into a secretable compartment, probably the catecholamine-containing chromaffin vesicles.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Mechanistic Insights and Functional Determinants of the Transport Cycle of the Ascorbic Acid Transporter SVCT2: ACTIVATION BY SODIUM AND ABSOLUTE DEPENDENCE ON BIVALENT CATIONS.
A. Godoy, V. Ormazabal, G. Moraga-Cid, F. A. Zuniga, P. Sotomayor, V. Barra, O. Vasquez, V. Montecinos, L. Mardones, C. Guzman, et al. (2007)
J. Biol. Chem. 282, 615-624
   Abstract »    Full Text »    PDF »
Trypanosoma cruzi expresses a plant-like ascorbate-dependent hemoperoxidase localized to the endoplasmic reticulum.
S. R. Wilkinson, S. O. Obado, I. L. Mauricio, and J. M. Kelly (2002)
PNAS 99, 13453-13458
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Ascorbic acid acts as an inhibitory transmitter in the hypothalamus to inhibit stimulated luteinizing hormone-releasing hormone release by scavenging nitric oxide.
S. Karanth, W. H. Yu, A. Walczewska, C. Mastronardi, and S. M. McCann (2000)
PNAS 97, 1891-1896
   Abstract »    Full Text »    PDF »
Release of Endogenous Ascorbic Acid Preserves Extracellular Dopamine in the Mammalian Retina.
M. J. Neal, J. R. Cunningham, and K. L. Matthews (1999)
Invest. Ophthalmol. Vis. Sci. 40, 2983-2987
   Abstract »    Full Text »    PDF »
Colony-Stimulating Factors Signal for Increased Transport of Vitamin C in Human Host Defense Cells.
J. C. Vera, C. I. Rivas, R. H. Zhang, and D. W. Golde (1998)
Blood 91, 2536-2546
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Protein-disulfide Isomerase- and Protein Thiol-dependent Dehydroascorbate Reduction and Ascorbate Accumulation in the Lumen of the Endoplasmic Reticulum.
G. Nardai, L. Braun, M. Csala, V. Mile, P. Csermely, A. Benedetti, J. Mandl, and G. Banhegyi (2001)
J. Biol. Chem. 276, 8825-8828
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