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Science 23 April 1982:
Vol. 216. no. 4544, pp. 434 - 436
DOI: 10.1126/science.7071592
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Articles

Science, Vol 216, Issue 4544, 434-436
Copyright © 1982 by American Association for the Advancement of Science

articles

Selective, naloxone-reversible morphine depression of learned behavioral and hippocampal responses

MD Mauk, JT Warren, and RF Thompson

Morphine administered intravenously causes immediate and complete abolition of a simple learned response (classically conditioned nictitating membrane extension in rabbit) and of the associated learning-induced increase in hippocampal neuron activity. Both effects are completely reversed by low doses of naloxone. Morphine has no effect at all on behavioral performance of the unconditioned reflex response.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Blockade of Endogenous Opioid Neurotransmission Enhances Acquisition of Conditioned Fear in Humans.
F. Eippert, U. Bingel, E. Schoell, J. Yacubian, and C. Buchel (2008)
J. Neurosci. 28, 5465-5472
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