Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 23 April 1982:
Vol. 216. no. 4544, pp. 415 - 417
DOI: 10.1126/science.7071589
Prev | Table of Contents | Next

Articles

Science, Vol 216, Issue 4544, 415-417
Copyright © 1982 by American Association for the Advancement of Science

articles

Systemic lupus erythematosus-like syndrome in monkeys fed alfalfa sprouts: role of a nonprotein amino acid

MR Malinow, EJ Bardana Jr, B Pirofsky, S Craig, and P McLaughlin

Hematologic and serologic abnormalities similar to those observed in human systemic lupus erythematosus (SLE) developed in cynomolgus macaques fed alfalfa sprouts. L-Canavanine sulfate, a constituent of alfalfa sprouts, was incorporated into the diet and reactivated the syndrome in monkeys in which an SLE-like syndrome had previously been induced by the ingestion of alfalfa seeds or sprouts.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The ethyl acetate extract of alfalfa sprout ameliorates disease severity of autoimmune-prone MRL-lpr/lpr mice.
Y. Hong, C. Huang, S. Wang, and B. Lin (2009)
Lupus 18, 206-215
   Abstract »    PDF »
The dietary supplement ephedrine induces b-adrenergic mediated exacerbation of systemic lupus erythematosus in NZM391 mice.
C A Hudson, T K Mondal, L Cao, J Kasten-Jolly, V C Huber, and D A Lawrence (2005)
Lupus 14, 293-307
   Abstract »    PDF »
Mortality and Morbidity in Laboratory-maintained Rhesus Monkeys and Effects of Long-term Dietary Restriction.
N. L. Bodkin, T. M. Alexander, H. K. Ortmeyer, E. Johnson, and B. C. Hansen (2003)
J. Gerontol. A Biol. Sci. Med. Sci. 58, B212-219
   Abstract »    Full Text »    PDF »
Diet and systemic lupus erythematosus: from mouse and monkey to woman?.
M Petri (2001)
Lupus 10, 775-777
   PDF »
Immunogenetically Controlled Autoimmune Reactions Induced by Mercury, Gold and D-Penicillamine in Laboratory Animals: a Review from the Vantage Point of Premarketing Safety Studies.
T. Balazs (1987)
Toxicology and Industrial Health 3, 331-336
   Abstract »    PDF »
Systemic Lupus Erythematosus: Insights from Animal Models.
A. D. STEINBERG, E. S. RAVECHE, C. A. LASKIN, H. R. SMITH, T. SANTORO, M. L. MILLER, and P. H. PLOTZ (1984)
Ann Intern Med 100, 714-727
   Abstract »    PDF »
Dietary carcinogens and anticarcinogens. Oxygen radicals and degenerative diseases.
B. Ames (1983)
Science 221, 1256-1264
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)