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Science 16 April 1982:
Vol. 216. no. 4543, pp. 305 - 307
DOI: 10.1126/science.6278597
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Articles

Science, Vol 216, Issue 4543, 305-307
Copyright © 1982 by American Association for the Advancement of Science

articles

Interaction of brain synaptic vesicles induced by endogenous Ca2+ -dependent phospholipase A2

N Moskowitz, W Schook, and S Puszkin

Endogenous phospholipase A2 activity of brain synaptic vesicles was Ca2+ -dependent and was increased by prostaglandin F2 alpha, calmodulin, adenosine 3', 5' -monophosphate, and adenosine triphosphate, whereas the activity was inhibited by prostaglandin E2 in the absence or presence of calmodulin. Light-scattering measurements demonstrated that stimulation of the enzyme's activity correlated with the induction of vesicle-vesicle aggregation. The effects of these compounds on endogenous synaptic vesicle phospholipase A2 activity may imply a common end point of their purported neuromodulatory actions, and indicate that synaptic vesicle phospholipase A2 may play a central role in presynaptic neurotransmission.


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