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Science 2 April 1982:
Vol. 216. no. 4541, pp. 78 - 80
DOI: 10.1126/science.6121375
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Articles

Science, Vol 216, Issue 4541, 78-80
Copyright © 1982 by American Association for the Advancement of Science

articles

Aspartate: possible neurotransmitter in cerebellar climbing fibers

L Wiklund, G Toggenburger, and M Cuenod

Autoradiography demonstrated prominent retrograde labeling of olivocerebellar climbing fiber neurons after injection of tritiated D-aspartate into the rat cerebellar cortex or deep nuclei. Mossy fiber systems originating in the brainstem and spinal cord remained unlabeled. Potassium ion-induced depolarization of cerebellar slices resulted in calcium ion-dependent release of endogenous L-aspartate, L-glutamate, gamma-aminobutyric acid, and glycine. A 26 percent decrease in aspartate release was observed after 3-acetylpyridine-induced destruction of the inferior olive, supporting the hypothesis that aspartate is a neurotransmitter in climbing fibers.


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