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Science 2 April 1982:
Vol. 216. no. 4541, pp. 57 - 59
DOI: 10.1126/science.7063870
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Articles

Science, Vol 216, Issue 4541, 57-59
Copyright © 1982 by American Association for the Advancement of Science

articles

Cytochrome P-450-dependent monooxygenases in olfactory epithelium of dogs: possible role in tumorigenicity

AR Dahl, WM Hadley, FF Hahn, JM Benson, and RO McClellan

The respiratory tract epithelium of dogs, from the nose to the lungs, was examined for cytochrome P-450 and associated biotransformation activities. In the ethmoturbinates, where olfactory epithelium is located, the amount of cytochrome P-450 was comparable to that in the liver, when measured on the basis of activity per milligram of microsomal protein. The rest of the nasal region also contained large quantities of cytochrome P-450. The presence of these enzymes in the nose may be important in chemical-induced tumorigenesis. The nasal carcinogen hexamethyl-phosphoramide was shown to be metabolized by nasal microsomal enzymes to another nasal carcinogen, formaldehyde.


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Tissue-Specific Metabolism of Benzene in Zymbal Gland and Other Solid Tumor Target Tissues in Rats.
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