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Science 19 March 1982:
Vol. 215. no. 4539, pp. 1523 - 1525
DOI: 10.1126/science.6121374
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Articles

Science, Vol 215, Issue 4539, 1523-1525
Copyright © 1982 by American Association for the Advancement of Science

articles

Opiates and pain pathways: demonstration of enkephalin synapses on dorsal horn projection neurons

MA Ruda

The participation of the opiate peptide enkephalin in the neural circuitry of the dorsal horn was examined at the light and ultrastructural level through the use of the combined techniques of immunocytochemistry and retrograde transport of horseradish peroxidase. Enkephalin immunoreactive axonal endings made direct synaptic contact with the soma and proximal dendrites of dorsal horn thalamic projection neurons. This observation demonstrates that one major synaptic site of enkephalin modulation of the transfer of nociceptive information in the dorsla horn is on the projection neurons themselves.U


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Hypersensitivity of Spinothalamic Tract Neurons Associated With Diabetic Neuropathic Pain in Rats.
S.-R. Chen and H.-L. Pan (2002)
J Neurophysiol 87, 2726-2733
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Endogenous Opioid Peptides Acting at µ-Opioid Receptors in the Dorsal Horn Contribute to Midbrain Modulation of Spinal Nociceptive Neurons.
D. Budai and H. L. Fields (1998)
J Neurophysiol 79, 677-687
   Abstract »    Full Text »    PDF »
Opiate receptor knockout mice define µ receptor roles in endogenous nociceptive responses and morphine-induced analgesia.
I. Sora, N. Takahashi, M. Funada, H. Ujike, R. S. Revay, D. M. Donovan, L. L. Miner, and G. R. Uhl (1997)
PNAS 94, 1544-1549
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