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Science 19 March 1982:
Vol. 215. no. 4539, pp. 1520 - 1522
DOI: 10.1126/science.7199758
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Articles

Science, Vol 215, Issue 4539, 1520-1522
Copyright © 1982 by American Association for the Advancement of Science

articles

Opioid-like analgesia in defeated mice

KA Miczek, ML Thompson, and L Shuster

Mice exposed to repeated attacks by other mice showed decreased nociception in response to radiant heat focused on their tails. This form of analgesia was blocked by centrally acting opiate antagonists and was not observed in morphine-tolerant mice; furthermore, mice repeatedly subjected to defeat. Mice of the CXBK strain, which respond weakly to morphine, displayed only moderate analgesia following defeat. These findings suggest that endogenous opioid-mediated analgesic mechanisms are readily activated by situations involving biologically significant forms of stress, such as defeat.


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