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Science 19 March 1982:
Vol. 215. no. 4539, pp. 1513 - 1515
DOI: 10.1126/science.7063858
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Articles

Science, Vol 215, Issue 4539, 1513-1515
Copyright © 1982 by American Association for the Advancement of Science

articles

Congenital malformations induced by laetrile

CC Willhite

Laetrile administered orally ot pregnant hamsters caused skeletal malformations in the offspring, but intravenous laetrile filed to result in embryopathic effects. Oral laetrile significantly increased in situ cyanide concentrations, while intravenous laetrile did not. Thiosulfate administration protected embryos from the teratogenic effects of oral laetrile. The embryopathic effects of oral laetrile appear to be due to cyanide released by bacterial beta-glucosidase activity.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)