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Science 12 March 1982:
Vol. 215. no. 4538, pp. 1411 - 1413
DOI: 10.1126/science.6278593
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Articles

Science, Vol 215, Issue 4538, 1411-1413
Copyright © 1982 by American Association for the Advancement of Science

articles

Long-term synaptic potentiation in the superior cervical ganglion

TH Brown and DA McAfee

Brief tetanic stimulation of the preganglionic nerves to the superior cervical ganglion enhances the postganglionic response to single preganglionic stimuli for 1 to 3 hours. This long-term potentiation of transmission through the ganglion is apparently not attributable to a persistent muscarinic action of the preganglionic neurotransmitter, acetylcholine, since neither the magnitude nor the time course of the phenomenon is reduced by atropine. The decay of long-term potentiation can be described by a first-order kinetic process with a mean time constant of 80 minutes. We conclude that long-term potentiation, once considered a unique property of the hippocampus, is in fact a more general feature of synaptic function. This form of synaptic memory may significantly influence information processing and control in other regions of the nervous system, including autonomic ganglia.


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