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Science 19 February 1982:
Vol. 215. no. 4535, pp. 989 - 991
DOI: 10.1126/science.6296999
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Articles

Science, Vol 215, Issue 4535, 989-991
Copyright © 1982 by American Association for the Advancement of Science

articles

Anti-inflammatory steroids without pituitary-adrenal suppression

HJ Lee and MR Soliman

When two new steroids, methyl prednisolonate and methyl 20-dihydroprednisolonate, were applied locally their anti-inflammatory activities were nearly equivalent to those of the parent compound prednisolone in the cotton pellet granuloma bioassay. However, when these two derivatives were administered systemically, their anti-inflammatory activities were weaker than those of the parent compound. Furthermore, unlike the parent compound, these new anti-inflammatory steroids did not suppress pituitary-adrenal function or cause liver glycogen depletion in rats.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Intrinsic Potencies of Novel Thiol Ester Corticosteroids RS-85095 and RS-21314 as Compared With Clobetasol 17-Propionate and Fluocinonide.
J. T. H. Ong, B. J. Poulsen, W. A. Akers, J. R. Scholtz, F. C. Genter, and D. J. Kertesz (1989)
Arch Dermatol 125, 1662-1665
   Abstract »    PDF »
Anti-inflammatory Adrenal Steroids That Neither Inhibit Skin Collagen Synthesis nor Cause Dermal Atrophy.
T. DiPetrillo, H. Lee, and K. R. Cutroneo (1984)
Arch Dermatol 120, 878-883
   Abstract »    PDF »


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