Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 19 February 1982:
Vol. 215. no. 4535, pp. 981 - 982
DOI: 10.1126/science.6186021
Prev | Table of Contents | Next

Articles

Science, Vol 215, Issue 4535, 981-982
Copyright © 1982 by American Association for the Advancement of Science

articles

Linkage analysis of nondeletion hereditary persistence of fetal hemoglobin

JM Old, H Ayyub, WG Wood, JB Clegg, and DJ Weatherall

Nondeletion forms of hereditary persistence of fetal hemoglobin may result from regulatory disorders of globin gene expression. The defects in two such conditions were localized by demonstrating a tight genetic linkage between the disorders and polymorphic restriction endonuclease sites within the beta-like globin gene complex. In one instance, the defect probably occurred outside the region of DNA between the epsilon- and beta-globin genes.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Control of fetal hemoglobin: new insights emerging from genomics and clinical implications.
S. L. Thein, S. Menzel, M. Lathrop, and C. Garner (2009)
Hum. Mol. Genet. 18, R216-R223
   Abstract »    Full Text »    PDF »
The Gene Map of Homo sapiens: Status and Prospectus.
V.A. McKusick (1986)
Cold Spring Harb Symp Quant Biol 51, 15-27
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)