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Science 5 February 1982:
Vol. 215. no. 4533, pp. 685 - 687
DOI: 10.1126/science.7036342
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Articles

Science, Vol 215, Issue 4533, 685-687
Copyright © 1982 by American Association for the Advancement of Science

articles

Uninvolved skin from psoriatic patients develops signs of involved psoriatic skin after being grafted onto nude mice

JE Fraki, RA Briggaman, and GS Lazarus

Clinically involved psoriatic epidermis maintains its histological appearance, increased labeling index, and increased level of plasminogen activator after being grafted onto athymic nude mice. Uninvolved psoriatic epidermis develops increases in plasminogen activator activity after being grafted onto athymic nude mice; this is accompanied by an increased labeling index. Thus, psoriatic skin can develop markers of psoriasis independent of the host.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Commentary: Cyclic Adenosine Monophosphate Regulation of Normal and Psoriatic Epidermis.
J. J. Voorhees (1982)
Arch Dermatol 118, 869-874
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