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Science 22 January 1982:
Vol. 215. no. 4531, pp. 415 - 416
DOI: 10.1126/science.7058326
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Articles

Science, Vol 215, Issue 4531, 415-416
Copyright © 1982 by American Association for the Advancement of Science

articles

Polyamines inhibit the protein kinase 380--catalyzed phosphorylation of eukaryotic initiation factor 2 alpha

Y Kuroda, WC Merrick, and RK Sharma

Polyamines putrescine, spermidine, and spermine specifically inhibit the PK 380--catalyzed phosphorylation of eukaryotic initiation factor 2 alpha (eIF-2 alpha). Since te PK 380--dependent phosphorylation of eIF-2 alpha inhibits the initiation or protein synthesis, the possibility exists that the polyamines enhance protein synthesis by inhibiting the phosphorylation of eIF-2 alpha by PK 380.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
A Dual Upstream Open Reading Frame-based Autoregulatory Circuit Controlling Polyamine-responsive Translation.
C. Hanfrey, K. A. Elliott, M. Franceschetti, M. J. Mayer, C. Illingworth, and A. J. Michael (2005)
J. Biol. Chem. 280, 39229-39237
   Abstract »    Full Text »    PDF »
Tumor suppression with a combination of alpha-difluoromethyl ornithine and interferon.
P. Sunkara, N. Prakash, G. Mayer, and A Sjoerdsma (1983)
Science 219, 851-853
   Abstract »    PDF »


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