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Science 22 January 1982:
Vol. 215. no. 4531, pp. 403 - 405
DOI: 10.1126/science.6800033
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Articles

Science, Vol 215, Issue 4531, 403-405
Copyright © 1982 by American Association for the Advancement of Science

articles

A 7-hydroxymethyl sulfate ester as an active metabolite of 7,12-dimethylbenz[alpha]anthracene

T Watabe, T Ishizuka, M Isobe, and N Ozawa

7-Hydroxymethyl-12-methylbenz[alpha]anthracene (7-HMBA), a carcinogenic major metabolite of 7,12-dimethylbenz[alpha]anthracene (DMBA) in liver, was transformed by liver cytosolic sulfotransferase to reactive 7-HMBA sulfate, which is mutagenic toward Salmonella typhimurium strain TA98. The mutagenicity of 7-HMBA in the presence of hepatic sulfotransferase was much higher than that of DMBA or 7-HMBA in the presence of hepatic monooxygenase.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Uptake of Chemically Reactive, DNA-Damaging Sulfuric Acid Esters into Renal Cells by Human Organic Anion Transporters.
N. Bakhiya, M. Stephani, A. Bahn, B. Ugele, A. Seidel, G. Burckhardt, and H. Glatt (2006)
J. Am. Soc. Nephrol. 17, 1414-1421
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A functional polymorphism in the SULT1A1 gene (G638A) is associated with risk of lung cancer in relation to tobacco smoking.
G. Liang, X. Miao, Y. Zhou, W. Tan, and D. Lin (2004)
Carcinogenesis 25, 773-778
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ENANTIOSELECTIVITY OF HUMAN HYDROXYSTEROID SULFOTRANSFERASE ST2A3 WITH NAPHTHYL-1-ETHANOLS.
J. J. Sheng and M. W. Duffel (2003)
Drug Metab. Dispos. 31, 697-700
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Single nucleotide polymorphisms, metabolic activation and environmental carcinogenesis: why molecular epidemiologists should think about enzyme expression.
J.A. Williams (2001)
Carcinogenesis 22, 209-214
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Benzylic hydroxylation of 1-methylpyrene and 1-ethylpyrene by human and rat cytochromes P450 individually expressed in V79 Chinese hamster cells.
W. Engst, R. Landsiedel, H. Hermersdorfer, J. Doehmer, and H. Glatt (1999)
Carcinogenesis 20, 1777-1785
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Molecular Cloning, Expression, and Characterization of Novel Human SULT1C Sulfotransferases That Catalyze the Sulfonation of N-Hydroxy-2-acetylaminofluorene.
Y. Sakakibara, K. Yanagisawa, J. Katafuchi, D. P. Ringer, Y. Takami, T. Nakayama, M. Suiko, and M.-C. Liu (1998)
J. Biol. Chem. 273, 33929-33935
   Abstract »    Full Text »    PDF »
Metabolic Activation of Xenobiotics: Ethylene Dibromide and Structural Analogs.
P. J. van Bladeren (1983)
International Journal of Toxicology 2, 73-83
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