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Science 15 January 1982:
Vol. 215. no. 4530, pp. 309 - 312
DOI: 10.1126/science.7053582
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Articles

Science, Vol 215, Issue 4530, 309-312
Copyright © 1982 by American Association for the Advancement of Science

articles

Iodine-125-labeled triiodothyronine in rat brain: evidence for localization in discrete neural systems

MB Dratman, Y Futaesaku, FL Crutchfield, N Berman, B Payne, M Sar, and WE Stumpf

Autoradiograms prepared from adult rat brains demonstrate that nerve cells and neuropil in different brain regions selectively concentrate and retain intravenously administered triiodothyronine, by mechanisms susceptible to saturation with excess triiodothyronine. A neuroregulatory role for thyroid hormones, strongly supported by the observations, may account for their marked effects on behavior and the activity of the autonomic nervous system.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)