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Science 8 January 1982:
Vol. 215. no. 4529, pp. 188 - 190
DOI: 10.1126/science.6171884
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Articles

Science, Vol 215, Issue 4529, 188-190
Copyright © 1982 by American Association for the Advancement of Science

articles

Substance P analog, DiMe-C7: evidence for stability in rat brain and prolonged central actions

AS Eison, SD Iversen, BE Sandberg, SP Watson, MR Hanley, and LL Iversen

A metabolically protected analog of substance P, [pGlu5-MePhe8-MeGly9]SP(5-11) (DiMe-C7), was approximately equipotent with substance P in causing increased locomotor activity after microinfusion into the ventral tegmental area of rat brain, but the effects of DiMe-C7 on behavior were considerably prolonged. There was little metabolic degradation of tritiated DiMe-C7 for up to 1 hour after infusion, whereas tritiated substance P was completely degraded within 10 minutes.


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