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Science 8 January 1982:
Vol. 215. no. 4529, pp. 187 - 188
DOI: 10.1126/science.7053570
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Articles

Science, Vol 215, Issue 4529, 187-188
Copyright © 1982 by American Association for the Advancement of Science

articles

Origin of the cholecystokinin-containing fibers in the rat caudatoputamen

DK Meyer, MC Beinfeld, WH Oertel, and MJ Brownstein

Large Amounts of cholecystokinin-octapeptide (CCK) are present in the rat caudatoputamen. The peptide occurs in axons and nerve endings but not in perikarya. The origin of CCK in the caudatoputamen was investigated with the use of immunocytochemistry and a radioimmunoassay specific for CCK. Although a small amount of CCK (approximately 30 percent) originates in the amygdaloid complex, the bulk of the peptide (approximately 70 percent) occurs in processes of neurons located ventral to the caudatoputamen, that is, the claustrum or the piriform cortex. The claustrum and piriform cortex receive inputs from various cortical areas and the olfactory system, respectively, and may process information and relay it to the caudatoputamen. Thus CCK may by the transmitter in the final common pathway linking various cortical areas and the olfactory system to the caudatoputamen.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Electrical Stimulation of the Prefrontal Cortex Increases Cholecystokinin, Glutamate, and Dopamine Release in the Nucleus Accumbens: an In Vivo Microdialysis Study in Freely Moving Rats.
Z.-B. You, T. M. Tzschentke, E. Brodin, and R. A. Wise (1998)
J. Neurosci. 18, 6492-6500
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