Science 8 January 1982: Vol. 215. no. 4529, pp. 185 - 187 DOI: 10.1126/science.7031900

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Nox4 Acts as a Switch Between Differentiation and Proliferation in Preadipocytes.

K. Schroder, K. Wandzioch, I. Helmcke, and R. P. Brandes (2009)
Arterioscler Thromb Vasc Biol 29, 239-245
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Abnormalities of Insulin-Like Growth Factor-I Signaling and Impaired Cell Proliferation in Osteoblasts from Subjects with Osteoporosis.

S. Perrini, A. Natalicchio, L. Laviola, A. Cignarelli, M. Melchiorre, F. De Stefano, C. Caccioppoli, A. Leonardini, S. Martemucci, G. Belsanti, et al. (2008)
Endocrinology 149, 1302-1313
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Molecular mechanism of bis(maltolato)oxovanadium(IV)-induced insulin signaling in 3T3-L1 and IM9 cells: impact of dexamethasone.

S. Bose, M A. Farah, H.-C. Jung, J.-H. Lee, and Y. Kim (2007)
J. Mol. Endocrinol. 38, 627-649
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The Novel Roles of Liver for Compensation of Insulin Resistance in Human Growth Hormone Transgenic Rats.

Y. Cho, M. Ariga, Y. Uchijima, K. Kimura, J.-Y. Rho, Y. Furuhata, F. Hakuno, K. Yamanouchi, M. Nishihara, and S.-I. Takahashi (2006)
Endocrinology 147, 5374-5384
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Molecular Mechanisms of Insulin Resistance: Serine Phosphorylation of Insulin Receptor Substrate-1 and Increased Expression of p85{alpha}: The Two Sides of a Coin..

B. Draznin (2006)
Diabetes 55, 2392-2397
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Insulin-Regulated Expression of Egr-1 and Krox20: Dependence on ERK1/2 and Interaction with p38 and PI3-Kinase Pathways.

A. B. Keeton, K. D. Bortoff, W. L. Bennett, J. L. Franklin, D. Y. Venable, and J. L. Messina (2003)
Endocrinology 144, 5402-5410
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Differential Activation of Phosphatidylinositol 3-Kinase Signaling during Proliferation and Differentiation of Lens Epithelial Cells.

G. Chandrasekher and D. Sailaja (2003)
Invest. Ophthalmol. Vis. Sci. 44, 4400-4411
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Insulin-induced Up-regulated Uncoupling Protein-1 Expression Is Mediated by Insulin Receptor Substrate 1 through the Phosphatidylinositol 3-Kinase/Akt Signaling Pathway in Fetal Brown Adipocytes.

A. M. Valverde, M. Arribas, C. Mur, P. Navarro, S. Pons, A.-M. Cassard-Doulcier, C. R. Kahn, and M. Benito (2003)
J. Biol. Chem. 278, 10221-10231
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Essential Role of Insulin-Like Growth Factor I Receptor in Insulin-Induced Fetal Brown Adipocyte Differentiation.

C. Mur, M. Arribas, M. Benito, and A. M. Valverde (2003)
Endocrinology 144, 581-593
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Exercise Effects on Muscle Insulin Signaling and Action: Exercise and insulin signaling: a historical perspective.

E. Tomas, A. Zorzano, and N. B. Ruderman (2002)
J Appl Physiol 93, 765-772
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Increased Insulin Sensitivity in IGF-I Receptor-Deficient Brown Adipocytes.

C. Mur, A. M. Valverde, C. R. Kahn, and M. Benito (2002)
Diabetes 51, 743-754
 |  Abstract »  |  Full Text »  |  PDF »

Distinct and Overlapping Functions of Insulin and IGF-I Receptors.

J. Nakae, Y. Kido, and D. Accili (2001)
Endocr. Rev. 22, 818-835
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Normal Akt/PKB with reduced PI3K activation in insulin-resistant mice.

S. T. Nadler, J. P. Stoehr, M. E. Rabaglia, K. L. Schueler, M. J. Birnbaum, and A. D. Attie (2001)
Am J Physiol Endocrinol Metab 281, E1249-E1254
 |  Abstract »  |  Full Text »  |  PDF »

Insulin Secretory Response Is Positively Associated with the Extent of Ossification of the Posterior Longitudinal Ligament of the Spine.

T. Akune, N. Ogata, A. Seichi, I. Ohnishi, K. Nakamura, H. Kawaguchi, S. L. Mayers, and W. D. Spotnitz (2001)
J. Bone Joint Surg. Am. 83, 1537-1544
 |  Abstract »  |  Full Text »  |  PDF »

Growth Hormone Induces Cellular Insulin Resistance by Uncoupling Phosphatidylinositol 3-Kinase and Its Downstream Signals in 3T3-L1 Adipocytes.

A. Takano, T. Haruta, M. Iwata, I. Usui, T. Uno, J. Kawahara, E. Ueno, T. Sasaoka, and M. Kobayashi (2001)
Diabetes 50, 1891-1900
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Subcellular Localization of Insulin Receptor Substrate Family Proteins Associated With Phosphatidylinositol 3-Kinase Activity and Alterations in Lipolysis in Primary Mouse Adipocytes From IRS-1 Null Mice.

Y. Tsuji, Y. Kaburagi, Y. Terauchi, S. Satoh, N. Kubota, H. Tamemoto, F. B. Kraemer, H. Sekihara, S. Aizawa, Y. Akanuma, et al. (2001)
Diabetes 50, 1455-1463
 |  Abstract »  |  Full Text »

Association of Insulin Receptor Substrate 1 (IRS-1) Y895 with Grb-2 Mediates the Insulin Signaling Involved in IRS-1-Deficient Brown Adipocyte Mitogenesis.

A. M. Valverde, C. Mur, S. Pons, A. M. Alvarez, M. F. White, C. R. Kahn, and M. Benito (2001)
Mol. Cell. Biol. 21, 2269-2280
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Insulin Receptor Substrate 3 (IRS-3) and IRS-4 Impair IRS-1- and IRS-2-Mediated Signaling.

K. Tsuruzoe, R. Emkey, K. M. Kriauciunas, K. Ueki, and C. R. Kahn (2001)
Mol. Cell. Biol. 21, 26-38
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Pathophysiology and Pharmacological Treatment of Insulin Resistance.

S. Matthaei, M. Stumvoll, M. Kellerer, and H.-U. Häring (2000)
Endocr. Rev. 21, 585-618
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A High Fructose Diet Affects the Early Steps of Insulin Action in Muscle and Liver of Rats.

R. M. N. Bezerra, M. Ueno, M. S. Silva, D. Q. Tavares, C. R. O. Carvalho, and M. J. A. Saad (2000)
J. Nutr. 130, 1531-1535
 |  Abstract »  |  Full Text »

Gab-1-mediated IGF-1 Signaling in IRS-1-deficient 3T3 Fibroblasts.

J. N. Winnay, J. C. Bruning, D. J. Burks, and C. R. Kahn (2000)
J. Biol. Chem. 275, 10545-10550
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Calmodulin Antagonists Inhibit Insulin-Stimulated GLUT4 (Glucose Transporter 4) Translocation by Preventing the Formation of Phosphatidylinositol 3,4,5-Trisphosphate in 3T3L1 Adipocytes.

C. Yang, R. T. Watson, J. S. Elmendorf, D. B. Sacks, and J. E. Pessin (2000)
Mol. Endocrinol. 14, 317-326
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Insulin Receptor at the Mouse Hepatocyte Nucleus after a Glucose Meal Induces Dephosphorylation of a 30-kDa Transcription Factor and a Concomitant Increase in Malic Enzyme Gene Expression.

N. Gletsu, W. Dixon, and M. T. Clandinin (1999)
J. Nutr. 129, 2154-2161
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Alterations in the early steps of the insulin-signaling system in skeletal muscle of GH-transgenic mice.

F. P. Dominici, D. Cifone, A. Bartke, and D. Turyn (1999)
Am J Physiol Endocrinol Metab 277, E447-E454
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The Insulin-Related Ovarian Regulatory System in Health and Disease.

L. Poretsky, N. A. Cataldo, Z. Rosenwaks, and L. C. Giudice (1999)
Endocr. Rev. 20, 535-582
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Action of Insulin Receptor Substrate-3 (IRS-3) and IRS-4 to Stimulate Translocation of GLUT4 in Rat Adipose Cells.

L. Zhou, H. Chen, P. Xu, L.-N. Cong, S. Sciacchitano, Y. Li, D. Graham, A. R. Jacobs, S. I. Taylor, and M. J. Quon (1999)
Mol. Endocrinol. 13, 505-514
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Correlation of alpha -Fetoprotein Expression in Normal Hepatocytes during Development with Tyrosine Phosphorylation and Insulin Receptor Expression.

L. Khamzina and P. Borgeat (1998)
Mol. Biol. Cell 9, 1093-1105
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Insulin-Like Growth Factor-I Is a Differentiation Factor for Postmitotic CNS Stem Cell-Derived Neuronal Precursors: Distinct Actions from Those of Brain-Derived Neurotrophic Factor.

Y. Arsenijevic and S. Weiss (1998)
J. Neurosci. 18, 2118-2128
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Insulin Resistance and the Polycystic Ovary Syndrome: Mechanism and Implications for Pathogenesis.

A. Dunaif (1997)
Endocr. Rev. 18, 774-800
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Expression of Variant Forms of Insulin Receptor Substrate-1 Identified in Patients with Noninsulin-Dependent Diabetes Mellitus.

Y. Imai, N. Philippe, G. Sesti, D. Accili, and S. I. Taylor (1997)
J. Clin. Endocrinol. Metab. 82, 4201-4207
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Insulin activation of phosphatidylinositol 3-kinase in human skeletal muscle in vivo.

M. S. Hickey, C. J. Tanner, D. S. O'Neill, L. J. Morgan, G. L. Dohm, and J. A. Houmard (1997)
J Appl Physiol 83, 718-722
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Alterations in the Insulin Signaling Pathway Induced by Immortalization and H-ras Transformation of Brown Adipocytes.

A. M. Valverde, M. Lorenzo, T. Teruel, and M. Benito (1997)
Endocrinology 138, 3195-3206
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Protein-tyrosine Phosphatase 1B Is a Negative Regulator of Insulin- and Insulin-like Growth Factor-I-stimulated Signaling.

K. A. Kenner, E. Anyanwu, J. M. Olefsky, and J. Kusari (1996)
J. Biol. Chem. 271, 19810-19816
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A Peptide-based Protein-tyrosine Phosphatase Inhibitor Specifically Enhances Insulin Receptor Function in Intact Cells.

H. K. Kole, M. J. Garant, S. Kole, and M. Bernier (1996)
J. Biol. Chem. 271, 14302-14307
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Replacements of Leucine 87 in Human Insulin Receptor Alter Affinity for Insulin.

J. Nakae, H. Morioka, E. Ohtsuka, and K. Fujieda (1995)
J. Biol. Chem. 270, 22017-22022
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Mitogen-activated Protein Kinase Kinase Inhibition Does Not Block the Stimulation of Glucose Utilization by Insulin.

D. F. Lazar, R. J. Wiese, M. J. Brady, C. C. Mastick, S. B. Waters, K. Yamauchi, J. E. Pessin, P. Cuatrecasas, and A. R. Saltiel (1995)
J. Biol. Chem. 270, 20801-20807
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The B Isoform of the Insulin Receptor Signals More Efficiently Than the A Isoform in HepG2 Cells.

A. Kosaki, T. S. Pillay, L. Xu, and N. J. G. Webster (1995)
J. Biol. Chem. 270, 20816-20823
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Decreased Phosphorylation of Mutant Insulin Receptor by Protein Kinase C and Protein Kinase A.

C. Miele, P. Formisano, K.-J. Sohn, M. Caruso, M. Pianese, G. Palumbo, L. Beguinot, and F. Beguinot (1995)
J. Biol. Chem. 270, 15844-15852
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Recombinant Human Insulin Receptor Substrate-1 Protein.

G. Siemeister, H. Al-Hasani, H. W. Klein, S. Kellner, Rüd. Streicher, W. Krone, and D. Müller-Wieland (1995)
J. Biol. Chem. 270, 4870-4874
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Activation of Mitogen-activated Protein Kinase and Phosphatidylinositol 3`-Kinase Is Not Sufficient for the Hormonal Stimulation of Glucose Uptake, Lipogenesis, or Glycogen Synthesis in 3T3-L1 Adipocytes.

R. J. Wiese, C. C. Mastick, D. F. Lazar, and A. R. Saltiel (1995)
J. Biol. Chem. 270, 3442-3446
 |  Abstract »  |  Full Text »  |  PDF »

IRS-1: essential for insulin- and IL-4-stimulated mitogenesis in hematopoietic cells.

L. Wang, M. Myers Jr, X. Sun, S. Aaronson, M White, and J. Pierce (1993)
Science 261, 1591-1594
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Human diabetes associated with a mutation in the tyrosine kinase domain of the insulin receptor.

M Odawara, T Kadowaki, R Yamamoto, Y Shibasaki, K Tobe, D Accili, C Bevins, Y Mikami, N Matsuura, Y Akanuma, et al. (1989)
Science 245, 66-68
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Blocking of EGF-dependent cell proliferation by EGF receptor kinase inhibitors.

P Yaish, A Gazit, C Gilon, and A Levitzki (1988)
Science 242, 933-935
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Role of Glycosyl Phosphoinositides in Insulin Action.

A.R. Saltiel, D.G. Osterman, and J.C. Darnell (1988)
Cold Spring Harb Symp Quant Biol 53, 955-963
 |  Abstract »  |  PDF »

After insulin binds.

O. Rosen (1987)
Science 237, 1452-1458
 |  Abstract »  |  PDF »

Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene.

L Coussens, T. Yang-Feng, Y. Liao, E Chen, A Gray, J McGrath, P. Seeburg, T. Libermann, J Schlessinger, U Francke, et al. (1985)
Science 230, 1132-1139
 |  Abstract »  |  PDF »

The insulin receptor contains a calmodulin-binding domain.

C. Graves, R. Goewert, and J. McDonald (1985)
Science 230, 827-829
 |  Abstract »  |  PDF »

Gene for human insulin receptor: localization to site on chromosome 19 involved in pre-B-cell leukemia.

T. Yang-Feng, U Francke, and A Ullrich (1985)
Science 228, 728-731
 |  Abstract »  |  PDF »

Immunoprecipitation of insulin receptors from cultured human lymphocytes (IM-9 cells) by antibodies to pp60src.

N Perrotti, S. Taylor, N. Richert, U. Rapp, I. Pastan, and J Roth (1985)
Science 227, 761-763
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Metabolic Importance of Acanthosis Nigricans.

J. S. Flier (1985)
Arch Dermatol 121, 193-194
 |  Abstract »  |  PDF »

Insulin receptor phosphorylation may not be a prerequisite for acute insulin action.

I. Simpson and J. Hedo (1984)
Science 223, 1301-1304
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Defect in phosphorylation of insulin receptors in cells from an insulin-resistant patient with normal insulin binding.

G Grunberger, Y Zick, and P Gorden (1984)
Science 223, 932-934
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Phosphorylation events during Mullerian duct regression.

J. Hutson, M. Fallat, S Kamagata, P. Donahoe, and G. Budzik (1984)
Science 223, 586-589
 |  Abstract »  |  PDF »

Insulin receptor: evidence that it is a protein kinase.

R. Roth and D. Cassell (1983)
Science 219, 299-301
 |  Abstract »  |  PDF »

Insulin Pharmacotherapy.

N. Datt (1973)
Clin-Alert 11, 260-270
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Activation of Insulin Signal Transduction Pathway and Anti-diabetic Activity of Small Molecule Insulin Receptor Activators.

S. A. Qureshi, V. Ding, Z. Li, D. Szalkowski, D. E. Biazzo-Ashnault, D. Xie, R. Saperstein, E. Brady, S. Huskey, X. Shen, et al. (2000)
J. Biol. Chem. 275, 36590-36595
 |  Abstract »  |  Full Text »  |  PDF »

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