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Science 8 January 1982:
Vol. 215. no. 4529, pp. 176 - 178
DOI: 10.1126/science.7053568
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Articles

Science, Vol 215, Issue 4529, 176-178
Copyright © 1982 by American Association for the Advancement of Science

articles

Tumor metastasis is not due to adaptation of cells to a new organ environment

GL Nicolson and SE Custead

Murine B16 melanoma cells were adapted for lung survival and growth by allowing them to attach to Bio-Carrier beads and injecting the beads intravenously into normal mice. The beads lodged mechanically in the microcirculation of the lung. When the melanoma cells had grown into visible tumors from the arrested beads, the tumors were removed and the cells were dispersed, cultured to remove normal cells, and reattached to new beads. The process was repeated nine times. Previously another B16 subline was injected intravenously as a suspension of separate tumor cells. Those cells that survived and colonized the lungs were harvested, cultured, and injected again. This selection process was also repeated nine times. Only the subline that was injected in suspension was more metastatic than the parental line, indicating that metastasis involves selection of preexistent metastatic cells and is not an adaptive process by which all cells gradually acquire the ability to grow at particular organ sites.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Experimental Liver Metastasis: Implications of Clonal Proclivity and Organ Specificity.
T. S. Ravikumar, J. D'Emilia, C. Cocchiaro, B. Wolf, V. King, and G. Steele Jr (1989)
Arch Surg 124, 49-54
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Combined Effect of Transfusion and Blood Groups on the Survival of Patients With Breast Cancer. A Clinical Study of 901 Patients {dagger}.
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Vascular and Endovascular Surgery 22, 402-412
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Atherosclerosis: I. A Leiomyoproliferative Disease of the Arteries Resulting from Breakdown of the Endothelial Barrier to Potent Blood Growth Factors II. Perspectives in Atheroprophylaxis.
S. DeCarvalho (1985)
Angiology 36, 697-710
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Biological diversity in metastatic neoplasms: origins and implications.
I. Fidler and I. Hart (1982)
Science 217, 998-1003
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Evidence for the clonal origin of spontaneous metastases.
J. Talmadge, Wolman SR, and I. Fidler (1982)
Science 217, 361-363
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