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Science 8 January 1982:
Vol. 215. no. 4529, pp. 168 - 170
DOI: 10.1126/science.6274021
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Articles

Science, Vol 215, Issue 4529, 168-170
Copyright © 1982 by American Association for the Advancement of Science

articles

Group B erythrocytes enzymatically converted to group O survive normally in A, B, and O individuals

J Goldstein, G Siviglia, R Hurst, L Lenny, and L Reich

With an alpha-galactosidase, B erythrocytes can be converted to blood group O under conditions that neither impair their viability in vitro nor affect their ability to survive normally after transfusion to individuals of groups O, A, and B. Such an approach has the potential for producing enzymatically converted group O cells for use in transfusion therapy. It should also be possible to convert A cells to group O by using the appropriate alpha-N-acetylgalactosaminidase.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Red Cell Antigens as Functional Molecules and Obstacles to Transfusion.
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Polyethylene glycol-coated red blood cells fail to bind glycophorin A-specific antibodies and are impervious to invasion by the Plasmodium falciparum malaria parasite.
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Cloning and High-Level Expression of alpha -Galactosidase cDNA from Penicillium purpurogenum.
H. Shibuya, H. Nagasaki, S. Kaneko, S. Yoshida, G. G. Park, I. Kusakabe, and H. Kobayashi (1998)
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Purification and Characterization of Blood Group A-degrading Isoforms of alpha -N-Acetylgalactosaminidase from Ruminococcus torques Strain IX-70.
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