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Science 1 January 1982:
Vol. 215. no. 4528, pp. 71 - 73
DOI: 10.1126/science.6274020
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Articles

Science, Vol 215, Issue 4528, 71-73
Copyright © 1982 by American Association for the Advancement of Science

articles

Epinephrine reduction of heme: implication for understanding the transmission of an agonist stimulus

DA Peterson, JM Gerrard, SM Glover, GH Rao, and JG White

Alpha-adrenergic agonists that promote platelet aggregation were found to reduce ferric heme to ferrous heme. Agents that bind iron in heme inhibited epinephrine-induced platelet aggregation. It is proposed that epinephrine first binds to its receptor and then reduces an adjacent heme group to transmit its agonist stimulus.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Evidence for a novel thioredoxin-like catalytic property of gonadotropic hormones.
J. Boniface and L. Reichert Jr (1990)
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