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Science 11 December 1981:
Vol. 214. no. 4526, pp. 1261 - 1262
DOI: 10.1126/science.6117947
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Articles

Science, Vol 214, Issue 4526, 1261-1262
Copyright © 1981 by American Association for the Advancement of Science

articles

Neuroleptic drug-induced dopamine receptor supersensitivity: antagonism by L-prolyl-L-leucyl-glycinamide

S Chiu, CS Paulose, and RK Mishra

An animal model of tardive dyskinesia was used to evaluate the potential antidyskinetic properties of the neuropeptide L-prolyl-L-leucyl-glycinamide (PLG). In rats, PLG administered concurrently with the neuroleptic drug haloperidol or chlorpromazine antagonized the enhancement of specific [3H]spiroperidol binding in the striatum that is associated with long-term neuroleptic treatment. The results are discussed in relation to a possible functional coupling of the putative PLG receptor with neuroleptic-dopamine receptor complex and clinical implications for tardive dyskinesia.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Persistent Spontaneous Oral Dyskinesias in Haloperidol-Withdrawn Rats Neonatally Lesioned with 6-Hydroxydopamine: Absence of an Association with the Bmax for [3H]Raclopride Binding to Neostriatal Homogenates.
N.-Y. Huang, R. M. Kostrzewa, C. Li, K. W. Perry, and R. W. Fuller (1997)
J. Pharmacol. Exp. Ther. 280, 268-276
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