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Science 27 November 1981:
Vol. 214. no. 4524, pp. 1034 - 1036
DOI: 10.1126/science.7029713
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Articles

Science, Vol 214, Issue 4524, 1034-1036
Copyright © 1981 by American Association for the Advancement of Science

articles

Vertebrate cell cycle modulates infection by protozoan parasites

JA Dvorak and MS Crane

Synchronized HeLa cell populations were exposed to Trypanosoma cruzi or Toxoplasma gondii, obligate intracellular protozoan parasites that cause Chagas' disease and toxoplasmosis, respectively, in humans. The ability of the two parasites to infect HeLa cells increased as the HeLa cells proceeded from the G1 phase to the S phase of their growth cycle and decreased as the cells entered G2-M. Characterization of the S-phase cell surface components responsible for this phenomenon could be beneficial in the development of vaccines against these parasitic diseases.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Modulation of the Host Cell Proteome by the Intracellular Apicomplexan Parasite Toxoplasma gondii.
M. M. Nelson, A. R. Jones, J. C. Carmen, A. P. Sinai, R. Burchmore, and J. M. Wastling (2008)
Infect. Immun. 76, 828-844
   Abstract »    Full Text »    PDF »
Lytic Cycle of Toxoplasma gondii.
M. W. Black and J. C. Boothroyd (2000)
Microbiol. Mol. Biol. Rev. 64, 607-623
   Abstract »    Full Text »    PDF »


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