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Science 20 November 1981:
Vol. 214. no. 4523, pp. 936 - 938
DOI: 10.1126/science.6795717
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Articles

Science, Vol 214, Issue 4523, 936-938
Copyright © 1981 by American Association for the Advancement of Science

articles

Fetal alcohol syndrome: embryogenesis in a mouse model

KK Sulik, MC Johnston, and MA Webb

When two small doses of ethanol were administered to pregnant mice during the gastrulation stage of embryogenesis, the embryos developed craniofacial malformations closely resembling those seen in the human fetal alcohol syndrome. Striking histological changes appeared in the developing brain (neuroectoderm) within 24 hours of exposure. Decreased development of the neural plate and its derivatives apparently accounts for the craniofacial malformations. The critical exposure period is equivalent to the third week in human pregnancy.


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