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Science 20 November 1981:
Vol. 214. no. 4523, pp. 931 - 933
DOI: 10.1126/science.6171034

Articles

Science, Vol 214, Issue 4523, 931-933
Copyright © 1981 by American Association for the Advancement of Science


articles

Axonal elongation into peripheral nervous system "bridges" after central nervous system injury in adult rats

S David and AJ Aguayo

The origin, termination, and length of axonal growth after focal central nervous system injury was examined in adult rats by means of a new experimental model. When peripheral nerve segments were used as "bridges" between the medulla and spinal cord, axons from neurons at both these levels grew approximately 30 millimeters. The regenerative potential of these central neurons seems to be expressed when the central nervous system glial environment is changed to that of the peripheral nervous system.


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