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Science 13 November 1981:
Vol. 214. no. 4522, pp. 809 - 810
DOI: 10.1126/science.6270793
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Articles

Science, Vol 214, Issue 4522, 809-810
Copyright © 1981 by American Association for the Advancement of Science

articles

Increased pyrophosphate in fibroblasts and lymphoblasts from patients with hereditary diffuse articular chondrocalcinosis

G Lust, G Faure, P Netter, and JE Seegmiller

The metabolic and genetic factors leading to deposition of calcium pyrophosphate crystals in cartilage of patients with chondrocalcinosis are not well understood. Analysis of cultured fibroblasts and lymphoblasts from 12 affected members of a large kindred showed a mean concentration of intracellular inorganic pyrophosphate two times greater than that in cells from unaffected family members or normal, unrelated volunteers. Increased intracellular pyrophosphate may, therefore, be a biochemical marker for the heterozygous expression of the chondrocalcinosis gene.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Role of the Mouse ank Gene in Control of Tissue Calcification and Arthritis.
A. M. Ho, M. D. Johnson, and D. M. Kingsley (2000)
Science 289, 265-270
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