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Science 6 November 1981:
Vol. 214. no. 4521, pp. 669 - 671
DOI: 10.1126/science.7027442
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Articles

Science, Vol 214, Issue 4521, 669-671
Copyright © 1981 by American Association for the Advancement of Science

articles

Thymosin stimulates secretion of luteinizing hormone-releasing factor

RW Rebar, A Miyake, TL Low, and AL Goldstein

Partially purified thymosin fraction 5 and one of its synthetic peptide components, thymosin beta 4, but not thymosin alpha 1, stimulated secretion of luteinizing hormone--releasing factor from superfused medial basal hypothalami from random cycling female rats. In addition, luteinizing hormone was released from pituitary glands superfused in sequence with hypothalami. No release of luteinizing hormone in response to thymosin was observed from pituitaries superfused alone. These data provide the first evidence of a direct effect of the endocrine thymus on the hypothalamus and suggest a potentially important role for thymic peptides in reproductive function.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Neuroendocrine Control of Thymus Physiology.
W. Savino and M. Dardenne (2000)
Endocr. Rev. 21, 412-443
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The neuroendocrine thymus: coexistence of oxytocin and neurophysin in the human thymus.
V Geenen, J. Legros, P Franchimont, M Baudrihaye, M. Defresne, and J Boniver (1986)
Science 232, 508-511
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The thymus-adrenal connection: thymosin has corticotropin-releasing activity in primates.
D. Healy, G. Hodgen, H. Schulte, G. Chrousos, D. Loriaux, N. Hall, and A. Goldstein (1983)
Science 222, 1353-1355
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